UBQLN4 antibody (Internal Region)

Catalog No. ABIN6259665

Product Details anti-UBQLN4 Antibody

Target: UBQLN4 (Ubiquilin 4 (UBQLN4))

Binding Specificity: Internal Region

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UBQLN4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Specificity: A1Up Antibody detects endogenous levels of total A1Up.

Predicted Reactivity: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human A1Up, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:1000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for UBQLN4

Target: UBQLN4 (Ubiquilin 4 (UBQLN4))

Alternative Name: UBQLN4 (UBQLN4 Products)

Synonyms: a1u antibody, cip75 antibody, ubin antibody, ubiquilin-4 antibody, A1U antibody, A1Up antibody, C1orf6 antibody, CIP75 antibody, UBIN antibody, A1u antibody, AI663987 antibody, RGD1308273 antibody, ubiquilin 4 L homeolog antibody, ubiquilin 4 antibody, ubqln4.L antibody, ubqln4 antibody, UBQLN4 antibody, Ubqln4 antibody

Background:

Description: Plays a role in the regulation of protein degradation via the ubiquitin-proteasome system (UPS). Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (PubMed:15280365). Plays a role in the regulation of the proteasomal degradation of non-ubiquitinated GJA1 (By similarity). Acts as an adapter protein that recruits UBQLN1 to the autophagy machinery. Mediates the association of UBQLN1 with autophagosomes and the autophagy-related protein LC3 (MAP1LC3A/B/C) and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:23459205).

Gene: UBQLN4

Molecular Weight: 54kDa

Gene ID: 56893

UniProt: Q9NRR5