Antizyme Inhibitor 1 antibody (Internal Region)

Catalog No. ABIN6259946

Product Details anti-Antizyme Inhibitor 1 Antibody

Target: Antizyme Inhibitor 1 (AZIN1)

Binding Specificity: Internal Region

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Antizyme Inhibitor 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificity: Antizyme inhibitor 1 Antibody detects endogenous levels of total Antizyme inhibitor 1.

Predicted Reactivity: Pig,Bovine,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human Antizyme inhibitor 1, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for Antizyme Inhibitor 1

Target: Antizyme Inhibitor 1 (AZIN1)

Alternative Name: AZIN1 (AZIN1 Products)

Synonyms: OAZI antibody, OAZIN antibody, ODC1L antibody, 1700085L02Rik antibody, AI414949 antibody, Oazi antibody, Oazin antibody, AZIN1 antibody, azin1 antibody, oazin antibody, wu:fj32d12 antibody, MGC81852 antibody, wu:fc93f10 antibody, zgc:110131 antibody, antizyme inhibitor 1 antibody, antizyme inhibitor 1b antibody, antizyme inhibitor 1 L homeolog antibody, antizyme inhibitor 1a antibody, AZIN1 antibody, Azin1 antibody, azin1b antibody, azin1.L antibody, azin1 antibody, azin1a antibody

Background:

Description: Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding (PubMed:17900240, PubMed:26305948). Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production (PubMed:17900240).

Gene: AZIN1

Molecular Weight: 49.5 kDa

Gene ID: 51582

UniProt: O14977