CCRN4L antibody
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- Target See all CCRN4L Antibodies
- CCRN4L (CCR4 Carbon Catabolite Repression 4-Like (CCRN4L))
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Reactivity
- Human, Rat, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This CCRN4L antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA
- Specificity
- CCRN4L Antibody detects endogenous levels of total CCRN4L
- Cross-Reactivity
- Human, Mouse (Murine), Rat (Rattus)
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human CCRN4L
- Isotype
- IgG
- Top Product
- Discover our top product CCRN4L Primary Antibody
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- Application Notes
- WB 1:1000-3000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C.Stable for 12 months from date of receipt
- Expiry Date
- 12 months
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- Target
- CCRN4L (CCR4 Carbon Catabolite Repression 4-Like (CCRN4L))
- Alternative Name
- CCRN4L (CCRN4L Products)
- Synonyms
- CCR4L antibody, NOC antibody, AU043840 antibody, Ccr4 antibody, nocturnin antibody, Ccrn4lb antibody, MNOC antibody, ccr4l antibody, noc antibody, MGC85016 antibody, ccrn4l antibody, CCRN4L antibody, nocturnin antibody, nocturnin S homeolog antibody, nocturnin L homeolog antibody, putative nocturnin antibody, NOCT antibody, Noct antibody, noct antibody, noct.S antibody, noct.L antibody, LOC5570471 antibody, CpipJ_CPIJ011434 antibody, Smp_105040 antibody
- Background
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Description: Circadian deadenylase which plays an important role in post-transcriptional regulation of metabolic genes under circadian control. Degrades poly(A) tails of specific target mRNAs leading to their degradation and suppression of translation. Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis. Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance. Promotes adipogenesis by activating PPARG transcriptional activity in a deadenylase-independent manner by facilitating its nuclear translocation. Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone. Critical for proper development of early embryos (By similarity).
Gene: NOCT
- Molecular Weight
- 48 kDa
- Gene ID
- 25819
- UniProt
- Q9UK39
- Pathways
- Ribonucleoprotein Complex Subunit Organization
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