CCRN4L antibody

Catalog No. ABIN6260565

Product Details anti-CCRN4L Antibody

Target: CCRN4L (CCR4 Carbon Catabolite Repression 4-Like (CCRN4L))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CCRN4L antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: CCRN4L Antibody detects endogenous levels of total CCRN4L

Cross-Reactivity: Human, Mouse (Murine), Rat (Rattus)

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human CCRN4L

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C.Stable for 12 months from date of receipt

Expiry Date: 12 months

Target Details for CCRN4L

Target: CCRN4L (CCR4 Carbon Catabolite Repression 4-Like (CCRN4L))

Alternative Name: CCRN4L (CCRN4L Products)

Synonyms: CCR4L antibody, NOC antibody, AU043840 antibody, Ccr4 antibody, nocturnin antibody, Ccrn4lb antibody, MNOC antibody, ccr4l antibody, noc antibody, MGC85016 antibody, ccrn4l antibody, CCRN4L antibody, nocturnin antibody, nocturnin S homeolog antibody, nocturnin L homeolog antibody, putative nocturnin antibody, NOCT antibody, Noct antibody, noct antibody, noct.S antibody, noct.L antibody, LOC5570471 antibody, CpipJ_CPIJ011434 antibody, Smp_105040 antibody

Background:

Description: Circadian deadenylase which plays an important role in post-transcriptional regulation of metabolic genes under circadian control. Degrades poly(A) tails of specific target mRNAs leading to their degradation and suppression of translation. Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis. Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance. Promotes adipogenesis by activating PPARG transcriptional activity in a deadenylase-independent manner by facilitating its nuclear translocation. Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone. Critical for proper development of early embryos (By similarity).

Gene: NOCT

Molecular Weight: 48 kDa

Gene ID: 25819

UniProt: Q9UK39

Pathways: Ribonucleoprotein Complex Subunit Organization