CLASP2 antibody
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- Target See all CLASP2 Antibodies
- CLASP2 (Cytoplasmic Linker Associated Protein 2 (CLASP2))
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This CLASP2 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA
- Specificity
- CLASP2 Antibody detects endogenous levels of total CLASP2
- Cross-Reactivity
- Human
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human CLASP2
- Isotype
- IgG
- Top Product
- Discover our top product CLASP2 Primary Antibody
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- Application Notes
- WB 1:1000-3000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C.Stable for 12 months from date of receipt
- Expiry Date
- 12 months
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- Target
- CLASP2 (Cytoplasmic Linker Associated Protein 2 (CLASP2))
- Alternative Name
- CLASP2 (CLASP2 Products)
- Synonyms
- zgc:77279 antibody, DKFZp459M112 antibody, 1500004F14Rik antibody, 8030404L10Rik antibody, C77448 antibody, CLASP2beta antibody, mKIAA0627 antibody, cytoplasmic linker associated protein 2 antibody, CLIP associating protein 2 antibody, clasp2 antibody, CLASP2 antibody, Clasp2 antibody
- Background
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Description: Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex.
Gene: CLASP2
- Molecular Weight
- 141kDa
- Gene ID
- 23122
- UniProt
- O75122
- Pathways
- Microtubule Dynamics, Maintenance of Protein Location
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