CYR61 antibody (Internal Region)
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- Target See all CYR61 Antibodies
- CYR61 (Cysteine-Rich, Angiogenic Inducer, 61 (CYR61))
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Binding Specificity
- Internal Region
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This CYR61 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)
- Specificity
- CYR61/CCN1 Antibody detects endogenous levels of total CYR61/CCN1.
- Predicted Reactivity
- Rabbit
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human CYR61/CCN1, corresponding to a region within the internal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product CYR61 Primary Antibody
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- Application Notes
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-500, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C. Stable for 12 months from date of receipt.
- Expiry Date
- 12 months
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- Target
- CYR61 (Cysteine-Rich, Angiogenic Inducer, 61 (CYR61))
- Alternative Name
- CYR61 (CYR61 Products)
- Synonyms
- CCN1 antibody, GIG1 antibody, IGFBP10 antibody, ccn1 antibody, gig1 antibody, Xcyr61 antibody, igfbp10 antibody, MGC69281 antibody, MGC69539 antibody, cyr61-l2 antibody, zgc:158158 antibody, CYR61 antibody, AI325051 antibody, Igfbp10 antibody, cysteine rich angiogenic inducer 61 antibody, cysteine-rich, angiogenic inducer, 61 antibody, cysteine-rich, angiogenic inducer, 61 like 2 antibody, cysteine rich protein 61 antibody, cysteine rich angiogenic inducer 61 S homeolog antibody, CYR61 antibody, Cyr61 antibody, cyr61 antibody, cyr61l2 antibody, cyr61.S antibody
- Background
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Description: Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.
Gene: CYR61
- Molecular Weight
- 42kDa
- Gene ID
- 3491
- UniProt
- O00622
- Pathways
- Positive Regulation of Endopeptidase Activity, Growth Factor Binding
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