HLA-DMB antibody (C-Term)

Catalog No. ABIN6262286

Product Details anti-HLA-DMB Antibody

Target: HLA-DMB (Major Histocompatibility Complex, Class II, DM beta (HLA-DMB))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HLA-DMB antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificity: HLA-DMB Antibody detects endogenous levels of total HLA-DMB.

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human HLA-DMB, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for HLA-DMB

Target: HLA-DMB (Major Histocompatibility Complex, Class II, DM beta (HLA-DMB))

Alternative Name: HLA-DMB (HLA-DMB Products)

Synonyms: RING7 antibody, D6S221E antibody, RT1.DMb antibody, RT1.Mb antibody, MHC-DMB antibody, major histocompatibility complex, class II, DM beta antibody, RT1 class II, locus DMb antibody, HLA-DMB antibody, RT1-DMb antibody, PATR-DMB antibody

Background:

Description: Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO.

Gene: HLA-DMB

Molecular Weight: 29 kDa

Gene ID: 3109

UniProt: P28068

Pathways: Cancer Immune Checkpoints