IGHG1 antibody

Catalog No. ABIN6262500

Product Details anti-IGHG1 Antibody

Target: IGHG1 (Immunoglobulin Heavy Constant gamma 1 (G1m Marker) (IGHG1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IGHG1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: IGHG1 Antibody detects endogenous levels of total IGHG1

Cross-Reactivity: Human

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human IGHG1

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C.Stable for 12 months from date of receipt

Expiry Date: 12 months

Target Details for IGHG1

Target: IGHG1 (Immunoglobulin Heavy Constant gamma 1 (G1m Marker) (IGHG1))

Alternative Name: IGHG1 (IGHG1 Products)

Synonyms: RGD1359539 antibody, IgG1 antibody, Igh-4 antibody, VH7183 antibody, immunoglobulin heavy constant gamma 1 antibody, immunoglobulin heavy constant gamma 1 (G1m marker) antibody, Ighg1 antibody, IGHG1 antibody

Background:

Description: Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).

Gene: IGHG1

UniProt: P01857