KCNJ10 antibody (Internal Region)

Catalog No. ABIN6262748

Product Details anti-KCNJ10 Antibody

Target: KCNJ10 (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 10 (KCNJ10))

Binding Specificity: Internal Region

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KCNJ10 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Specificity: KCNJ10 Antibody detects endogenous levels of total KCNJ10.

Predicted Reactivity: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human KCNJ10, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000, IHC 1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for KCNJ10

Target: KCNJ10 (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 10 (KCNJ10))

Alternative Name: KCNJ10 (KCNJ10 Products)

Synonyms: kir1.2 antibody, kir4.1 antibody, birk-10 antibody, MGC145926 antibody, BIR10 antibody, BIRK-1 antibody, Kir1.2 antibody, Kir4.1 antibody, BIRK-10 antibody, KCNJ13-PEN antibody, KIR1.2 antibody, KIR4.1 antibody, SESAME antibody, potassium channel, inwardly rectifying subfamily J, member 10 L homeolog antibody, potassium voltage-gated channel subfamily J member 10 antibody, potassium channel, inwardly rectifying subfamily J, member 10 antibody, potassium inwardly-rectifying channel, subfamily J, member 10 antibody, kcnj10.L antibody, KCNJ10 antibody, kcnj10 antibody, Kcnj10 antibody

Background:

Description: May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium, as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity). In the kidney, together with KCNJ16, mediates basolateral K+ recycling in distal tubules, this process is critical for Na+ reabsorption at the tubules.

Gene: KCNJ10

Molecular Weight: 43 kDa

Gene ID: 3766

UniProt: P78508

Pathways: Dicarboxylic Acid Transport, Regulation of long-term Neuronal Synaptic Plasticity