PSMB1 antibody (Internal Region)

Catalog No. ABIN6264474

Product Details anti-PSMB1 Antibody

Target: PSMB1 (Proteasome (Prosome, Macropain) Subunit, beta Type, 1 (PSMB1))

Binding Specificity: Internal Region

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PSMB1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Specificity: PSMB1 Antibody detects endogenous levels of total PSMB1.

Predicted Reactivity: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human PSMB1, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for PSMB1

Target: PSMB1 (Proteasome (Prosome, Macropain) Subunit, beta Type, 1 (PSMB1))

Alternative Name: PSMB1 (PSMB1 Products)

Synonyms: DDBDRAFT_0217063 antibody, DDBDRAFT_0232957 antibody, DDB_0217063 antibody, DDB_0232957 antibody, AA409053 antibody, C81484 antibody, Lmpc5 antibody, HC5 antibody, PMSB1 antibody, PSC5 antibody, wu:fc51f06 antibody, zgc:103665 antibody, proteasome subunit beta 1 antibody, 20S proteasome subunit beta-1 antibody, proteasome subunit beta type 1 antibody, proteasome (prosome, macropain) subunit, beta type 1 antibody, proteasome subunit beta 1 S homeolog antibody, psmb1 antibody, PSMB1 antibody, psmB1 antibody, LOC100286342 antibody, Psmb1 antibody, psmb1.S antibody

Background:

Description: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).

Gene: PSMB1

Molecular Weight: 26kDa

Gene ID: 5689

UniProt: P20618

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA