RBBP6 antibody (Internal Region)
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- Target See all RBBP6 Antibodies
- RBBP6 (Retinoblastoma Binding Protein 6 (RBBP6))
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Binding Specificity
- Internal Region
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Reactivity
- Human, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This RBBP6 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA
- Specificity
- RBBP6 Antibody detects endogenous levels of total RBBP6.
- Predicted Reactivity
- Pig,Bovine,Sheep,Rabbit,Dog,Chicken
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human RBBP6, corresponding to a region within the internal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product RBBP6 Primary Antibody
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- Application Notes
- WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C. Stable for 12 months from date of receipt.
- Expiry Date
- 12 months
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- Target
- RBBP6 (Retinoblastoma Binding Protein 6 (RBBP6))
- Alternative Name
- RBBP6 (RBBP6 Products)
- Synonyms
- MY038 antibody, P2P-R antibody, PACT antibody, RBQ-1 antibody, SNAMA antibody, 4933422O15Rik antibody, AI316869 antibody, BB233631 antibody, C030034J04Rik antibody, C77662 antibody, rbbp6 antibody, MGC75882 antibody, RBBP6 antibody, im:7158869 antibody, rbbp6l antibody, RB binding protein 6, ubiquitin ligase antibody, retinoblastoma binding protein 6, ubiquitin ligase antibody, retinoblastoma binding protein 6 antibody, RBBP6 antibody, Rbbp6 antibody, rbbp6 antibody
- Background
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Description: E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53, may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359).
Gene: RBBP6
- Molecular Weight
- 202 kDa
- Gene ID
- 5930
- UniProt
- Q7Z6E9
- Pathways
- Regulatory RNA Pathways
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