SLC8A1 antibody (Internal Region)

Catalog No. ABIN6265150

Product Details anti-SLC8A1 Antibody

Target: SLC8A1 (Solute Carrier Family 8 (Sodium/calcium Exchanger), Member 1 (SLC8A1))

Binding Specificity: Internal Region

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLC8A1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Specificity: SLC8A1 Antibody detects endogenous levels of total SLC8A1.

Predicted Reactivity: Pig,Bovine,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human SLC8A1, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000, IHC 1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for SLC8A1

Target: SLC8A1 (Solute Carrier Family 8 (Sodium/calcium Exchanger), Member 1 (SLC8A1))

Alternative Name: SLC8A1 (SLC8A1 Products)

Synonyms: NCX1 antibody, AI852629 antibody, AV344025 antibody, D930008O12Rik antibody, Ncx1 antibody, Ncx antibody, SLC8A1 antibody, ncx1n antibody, solute carrier family 8 member A1 antibody, solute carrier family 8 (sodium/calcium exchanger), member 1 antibody, solute carrier family 8 (sodium/calcium exchanger), member 1b antibody, sodium/calcium exchanger 1 antibody, SLC8A1 antibody, Slc8a1 antibody, slc8a1b antibody, Tsp_07038 antibody

Background:

Description: Mediates the exchange of one Ca2+ ion against three to four Na+ ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca2+ levels and Ca2+-dependent cellular processes (PubMed:1374913, PubMed:11241183, PubMed:1476165). Contributes to Ca2+ transport during excitation-contraction coupling in muscle. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca2+ levels due to release of Ca2+ stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca2+ from the cell during the next phase, so that cytoplasmic Ca2+ levels rapidly return to baseline. Required for normal embryonic heart development and the onset of heart contractions.

Gene: SLC8A1

Molecular Weight: 109kDa

Gene ID: 6546

UniProt: P32418

Pathways: Myometrial Relaxation and Contraction