TXNRD1 antibody (Internal Region)

Catalog No. ABIN6278319

Product Details anti-TXNRD1 Antibody

Target: TXNRD1 (Thioredoxin Reductase 1 (TXNRD1))

Binding Specificity: Internal Region

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TXNRD1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Specificity: TXNRD1 Antibody detects endogenous levels of total TXNRD1.

Predicted Reactivity: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human TXNRD1, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for TXNRD1

Target: TXNRD1 (Thioredoxin Reductase 1 (TXNRD1))

Alternative Name: TXNRD1 (TXNRD1 Products)

Synonyms: TrxR1 antibody, cb682 antibody, fb83a08 antibody, wu:fb83a08 antibody, GB14972 antibody, MGC85342 antibody, NADPH-dependent thioredoxin reductase C antibody, T32G6.20 antibody, T32G6_20 antibody, GRIM-12 antibody, TR antibody, TR1 antibody, TRXR1 antibody, TXNR antibody, Tr antibody, thioredoxin reductase 1 antibody, thioredoxin reductase 1 L homeolog antibody, NADPH-dependent thioredoxin reductase C antibody, ThioRedoXin Reductase antibody, TXNRD1 antibody, txnrd1 antibody, Trxr-1 antibody, txnrd1.L antibody, NTRC antibody, trxr-1 antibody, Txnrd1 antibody

Background:

Description: Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid.

Gene: TXNRD1

Molecular Weight: 55 kDa

Gene ID: 7296

UniProt: Q16881

Pathways: Regulation of Lipid Metabolism by PPARalpha, Regulation of Carbohydrate Metabolic Process, Cell RedoxHomeostasis