USP49 antibody (Internal Region)

Catalog No. ABIN6265930

Product Details anti-USP49 Antibody

Target: USP49 (Ubiquitin Specific Peptidase 49 (USP49))

Binding Specificity: Internal Region

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This USP49 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Specificity: USP49 Antibody detects endogenous levels of total USP49.

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human USP49, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000, IHC 1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for USP49

Target: USP49 (Ubiquitin Specific Peptidase 49 (USP49))

Alternative Name: USP49 (USP49 Products)

Synonyms: USP49 antibody, C330046L10Rik antibody, Gm545 antibody, ubiquitin specific peptidase 49 antibody, USP49 antibody, Usp49 antibody

Background:

Description: Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub). H2BK120Ub is a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Deubiquitination is required for efficient cotranscriptional splicing of a large set of exons.

Gene: USP49

Molecular Weight: 79 kDa

Gene ID: 25862

UniProt: Q70CQ1