OTUB1 antibody (Internal Region)

Catalog No. ABIN6282055

Product Details anti-OTUB1 Antibody

Target: OTUB1 (OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1))

Binding Specificity: AA 20-100, Internal Region

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OTUB1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purpose: Otubain-1 is a protein encoded by the OTUB1 gene which is approximately 31,3 kDa. Otubain-1 is localised to the cytoplasm and is involved in deubiquitination, metabolism of proteins, DNA damage and ovarian tumor domain proteases. Otubain-1 is a member of the ovarian tumor superfamily. It interacts with another ubiquitin protease and an E3 ubiquitin ligase whicj inhibits cytokine gene transcription in the immune system. It also plays a key non-catalytic role in DNA repair regulation by inhibiting activity of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of Lys-63-linked histone H2A and H2AX at DNA damage sites. Isoform 1 of otubain-1 is ubiquitously expressed while isoform 2 is expressed only in lymphoid tissues as well as peripheral blood mononuclear cells. Mutations in the OTUB1 gene may result in retinitis pigmentosa. STJ97632 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of otubain-1 protein.

Specificity: Otubain-1 Polyclonal Antibody detects endogenous levels of Otubain-1 protein.

Characteristics: Rabbit polyclonal to Otubain-1.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human Otubain-1

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000
ELISA 1:10000

Comment:

Isoform 1 is ubiquitous. Isoform 2 is expressed only in lymphoid tissues such as tonsils, lymph nodes and spleen, as well as peripheral blood mononuclear cells.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C, and avoid repeat freeze-thaw cycles.

Target Details for OTUB1

Target: OTUB1 (OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1))

Alternative Name: Otubain-1 (OTUB1 Products)

Synonyms: OTB1 antibody, OTU1 antibody, AI850305 antibody, fa19h07 antibody, otub1 antibody, wu:fa19h07 antibody, zgc:92839 antibody, MGC131231 antibody, fb17f04 antibody, otub1l antibody, wu:fb17f04 antibody, zgc:92685 antibody, OTU deubiquitinase, ubiquitin aldehyde binding 1 antibody, OTU domain, ubiquitin aldehyde binding 1 antibody, OTU deubiquitinase, ubiquitin aldehyde binding 1b antibody, OTU deubiquitinase, ubiquitin aldehyde binding 1 L homeolog antibody, similar to HSPC263 antibody, OTU deubiquitinase, ubiquitin aldehyde binding 1a antibody, OTUB1 antibody, Otub1 antibody, otub1b antibody, otub1.L antibody, otub1 antibody, RGD1565010 antibody, otub1a antibody

Gene ID: 55611

UniProt: Q96FW1