BMP2 antibody (C-Term)

Catalog No. ABIN6283442

Product Details anti-BMP2 Antibody

Target: BMP2 (Bone Morphogenetic Protein 2 (BMP2))

Binding Specificity: AA 341-390, C-Term

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BMP2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: BMP-2 is a protein encoded by the BMP2 gene which is approximately 44,7 kDa. BMP-2 is secreted into the extracellular space. It is involved in apoptotic pathways, PEDF induced signalling, the GPCR pathway and ERK signalling. This protein is a secreted ligand of the TGF-beta superfamily of proteins. It binds various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. It is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. BMP-2 is expressed in the bone, muscle, bone marrow, nervous system and lung. Mutations in the BMP2 gene may result in Cauda Equina syndrome. STJ97346 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of BMP-2 protein.

Specificity: BMP-2 Polyclonal Antibody detects endogenous levels of BMP-2 protein.

Characteristics: Rabbit polyclonal to BMP-2.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human BMP-2.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000
IHC-P 1:100-1:300
ELISA 1:10000

Comment:

Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C, and avoid repeat freeze-thaw cycles.

Target Details for BMP2

Target: BMP2 (Bone Morphogenetic Protein 2 (BMP2))

Alternative Name: BMP-2 (BMP2 Products)

Synonyms: BDA2 antibody, BMP2A antibody, AI467020 antibody, Bmp2a antibody, BMP-2 antibody, xBMP-2 antibody, xbmp2 antibody, BMP2 antibody, bmp2a antibody, bmp2 antibody, wu:fc59d09 antibody, bone morphogenetic protein 2 antibody, bone morphogenetic protein 2 L homeolog antibody, Bone morphogenetic protein 2 antibody, bone morphogenetic protein 2a antibody, BMP2 antibody, Bmp2 antibody, bmp2.L antibody, bmp2 antibody, bmp2a antibody

Gene ID: 650

UniProt: P12643

Pathways: Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Regulation of Muscle Cell Differentiation, Growth Factor Binding, Positive Regulation of fat Cell Differentiation