CEP290 antibody (Internal Region)

Catalog No. ABIN6284993

Product Details anti-CEP290 Antibody

Target: CEP290 (Centrosomal Protein 290kDa (CEP290))

Binding Specificity: AA 740-820, Internal Region

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CEP290 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF)

Purpose: CEP290 is a protein encoded by the CEP290 gene which is approximately 290,3 kDa. CEP290 is localised to the cytoplasm. It is involved in regulation of PLK1 activity at G2/M transition, innate immune system and mitotic cell cycle. It is a protein with 13 putative coiled-coil domains, a region with homology to SMC chromosome segregation ATPases, six KID motifs, three tropomyosin homology domains and an ATP/GTP binding site motif A. It is involved in the early and late steps of cilia formation. CEP290 is ubiquitously expressed with stronger expression in the placenta. Mutations in the CEP290 gene may result in Joubert syndrome. STJ92224 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of CEP290 protein.

Specificity: CEP290 Polyclonal Antibody detects endogenous levels of CEP290 protein.

Characteristics: Rabbit polyclonal to CEP290.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human CEP290

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000
ELISA 1:20000

Comment:

Ubiquitous. Expressed strongly in placenta and weakly in brain.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C, and avoid repeat freeze-thaw cycles.

Target Details for CEP290

Target: CEP290 (Centrosomal Protein 290kDa (CEP290))

Alternative Name: CEP290 (CEP290 Products)

Synonyms: ct87 antibody, mks4 antibody, rd16 antibody, bbs14 antibody, jbts5 antibody, jbts6 antibody, lca10 antibody, nphp6 antibody, slsn6 antibody, sh11ag antibody, MGC81471 antibody, 3h11ag antibody, RGD1311640 antibody, BC004690 antibody, Nphp6 antibody, b2b1454Clo antibody, b2b1752Clo antibody, im:7145703 antibody, im:7147820 antibody, 3H11Ag antibody, BBS14 antibody, CT87 antibody, JBTS5 antibody, LCA10 antibody, MKS4 antibody, NPHP6 antibody, POC3 antibody, SLSN6 antibody, centrosomal protein 290 antibody, centrosomal protein 290 L homeolog antibody, centrosomal protein 290kDa antibody, CEP290 antibody, cep290.L antibody, cep290 antibody, Cep290 antibody

Molecular Weight: 290 kDa

Gene ID: 80184

UniProt: O15078

Pathways: cAMP Metabolic Process, M Phase