ErbB2/Her2 antibody (N-Term)

Catalog No. ABIN6287432

Product Details anti-ErbB2/Her2 Antibody

Target: ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This ErbB2/Her2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: HER2 is a protein encoded by the ERBB2 gene which is approximately 137,9 kDa. HER2 isoform 1 is localised to the cell membrane and isoform 2 and 3 are localised to the cytoplasm and nucleus. It is involved in RET signalling, the GPCR pathway and signalling by ERBB2. It is a protein tyrosine kinase that is part of several cell surface receptor complexes that need a coreceptor for ligand binding. It is an essential component of a neuregulin-receptor complex and also regulates outgrowth and stabilization of peripheral microtubules. HER2 is expressed in the cells of the nervous system, liver, intestine, lymph nodes and lung. Mutations in the ERBB2 gene may result in Glioma. STJ96947 was developed from clone 11H9 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. The antibody detects endogenous ErbB-2/HER-2 proteins.

Specificity: The antibody detects endogenous ErbB-2/HER-2 proteins.

Characteristics: Mouse monoclonal to HER2.

Purification: The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

Immunogen: Synthetic Peptide

Clone: 11H9

Isotype: IgG1

Application Details

Application Notes: WB 1:2000-4000
IHC 1:200

Comment:

Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C, and avoid repeat freeze-thaw cycles.

Target Details for ErbB2/Her2

Target: ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

Alternative Name: HER2 (ErbB2/Her2 Products)

Synonyms: CD340 antibody, HER-2 antibody, HER-2/neu antibody, HER2 antibody, MLN 19 antibody, NEU antibody, NGL antibody, TKR1 antibody, Erbb-2 antibody, Neu antibody, c-erbB2 antibody, c-neu antibody, mKIAA3023 antibody, wu:fv70f10 antibody, zgc:63601 antibody, erb2 antibody, erb-b2 receptor tyrosine kinase 2 antibody, ERBB2 antibody, Erbb2 antibody, erbb2 antibody

Gene ID: 2064

UniProt: P04626

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Skeletal Muscle Fiber Development