Neuregulin 1 antibody (N-Term)

Catalog No. ABIN6287523

Product Details anti-Neuregulin 1 Antibody

Target: Neuregulin 1 (NRG1)

Binding Specificity: AA 1-80, N-Term

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Neuregulin 1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Purpose: Neuregulin-1 SMDF is a protein encoded by the NRG1 gene which is approximately 70,3 kDa. Neuregulin-1 SMDF is secreted and some isoforms are localised to the nucleus. It is involved in RET signalling, apoptotic pathways in synovial fibroblasts, GAB1 signalosome and the GPCR pathway. It mediates cell-cell signalling and plays a critical role in the growth and development of multiple organ systems. It is also a direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Neuregulin-1 SMDF isoform type 1 is the predominant form expressed in the endocardium. Mutations in the NRG1 gene may result in schizophrenia and bipolar disorder. STJ94419 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Neuregulin-1 SMDF protein.

Specificity: Neuregulin-1 SMDF Polyclonal Antibody detects endogenous levels of Neuregulin-1 SMDF protein.

Characteristics: Rabbit polyclonal to Neuregulin-1 SMDF.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human Neuregulin-1 SMDF

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:10000

Comment:

Type I isoforms are the predominant forms expressed in the endocardium. Isoform alpha is expressed in breast, ovary, testis, prostate, heart, skeletal muscle, lung, placenta liver, kidney, salivary gland, small intestine and brain, but not in uterus, stomach, pancreas, and spleen. Isoform 3 is the predominant form in mesenchymal cells and in non-neuronal organs, whereas isoform 6 is the major neuronal form. Isoform 8 is expressed in spinal cord and brain. Isoform 9 is the major form in skeletal muscle cells, in the nervous system it is expressed in spinal cord and brain. Also detected in adult heart, placenta, lung, liver, kidney, and pancreas. Isoform 10 is expressed in nervous system: spinal cord motor neurons, dorsal root ganglion neurons, and brain. Predominant isoform expressed in sensory and motor neurons. Not detected in adult heart, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Not expressed in fetal lung, liver and kidney. Type IV isoforms are brain-specific.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C, and avoid repeat freeze-thaw cycles.

Target Details for Neuregulin 1

Target: Neuregulin 1 (NRG1)

Alternative Name: Neuregulin-1 SMDF (NRG1 Products)

Synonyms: 6030402G23Rik antibody, ARIA antibody, D230005F13Rik antibody, GGF antibody, GGFII antibody, HRG antibody, HRGalpha antibody, Hgl antibody, NDF antibody, SMDF antibody, GGF2 antibody, HGL antibody, HRG1 antibody, HRGA antibody, MST131 antibody, NRG-1 antibody, heregulin antibody, nrg1-A antibody, pro-neuregulin-1 antibody, NRG1 antibody, wu:fm70e01 antibody, DKFZp459A1838 antibody, neuregulin 1 antibody, histidine rich glycoprotein antibody, neuregulin 1 L homeolog antibody, Nrg1 antibody, NRG1 antibody, HRG antibody, nrg1.L antibody, nrg1 antibody

Molecular Weight: 44 kDa

UniProt: Q02297

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation