MME antibody

Catalog No. ABIN6288762

Product Details anti-MME Antibody

Target: MME (Membrane Metallo-Endopeptidase (MME))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This MME antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: CD10 is a protein encoded by the MME gene which is approximately 85,5 kDa. CD10 is localised to the cell membrane. It is involved in the innate immune system, respiratory electron transport, peptide hormone metabolism and hematopoietic cell lineage. It is a common acute lymphocytic leukaemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukaemia. It acts as a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon and enkephalins. CD10 is expressed in the kidney, the cells of the nervous system, liver, blood and bone marrow. Mutations in the MME gene may result in Charcot-Marie-Tooth disease. STJ96974 was developed from clone 5B8 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. This antibody detects endogenous CD10 proteins.

Specificity: The antibody detects endogenous CD10 proteins.

Characteristics: Mouse monoclonal to CD10.

Purification: The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

Immunogen: Synthetic Peptide

Clone: 5B8

Isotype: IgG1

Application Details

Application Notes: IHC 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C, and avoid repeat freeze-thaw cycles.

Target Details for MME

Target: MME (Membrane Metallo-Endopeptidase (MME))

Alternative Name: CD10 (MME Products)

Synonyms: CALLA antibody, CD10 antibody, NEP antibody, SFE antibody, 6030454K05Rik antibody, C85356 antibody, Nep antibody, neprilysin antibody, membrane metalloendopeptidase antibody, membrane metallo endopeptidase antibody, membrane metallo-endopeptidase antibody, MME antibody, Mme antibody

Target Type: Chemical

Gene ID: 4311

UniProt: P08473

Pathways: RTK Signaling, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Smooth Muscle Cell Migration