IBTK antibody

Catalog No. ABIN6290521

Product Details anti-IBTK Antibody

Target: IBTK (Inhibitor of Bruton Agammaglobulinemia Tyrosine Kinase (IBTK))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IBTK antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Affinity purification

Immunogen: Recombinant protein of human IBTK

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000

Comment:

Expressed in DeFew, HEK293T, HeLa and in Jurkat, MC3 and NB4 lymphoid cells (at protein level), Isoform 1 is the predominant isoform expressed in all examined tissues and cell lines, Highly expressed in hemopoietic tissues (fetal liver, spleen, lymph node, thymus, peripheral blood leukocytes and bone marrow), Weakly or not expressed in other tissues

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20C. Avoid freeze / thaw cycles.

Target Details for IBTK

Target: IBTK (Inhibitor of Bruton Agammaglobulinemia Tyrosine Kinase (IBTK))

Alternative Name: IBTK (IBTK Products)

Synonyms: IBTK antibody, fi40c08 antibody, wu:fi40c08 antibody, DKFZp468J085 antibody, BTBD26 antibody, BTKI antibody, RP1-93K22.1 antibody, 5430411K16Rik antibody, AA409502 antibody, mKIAA1417 antibody, inhibitor of Bruton tyrosine kinase antibody, inhibitor of Bruton agammaglobulinemia tyrosine kinase antibody, inhibitor of Bruton tyrosine kinase L homeolog antibody, IBTK antibody, ibtk antibody, Ibtk antibody, ibtk.L antibody

Background: Bruton tyrosine kinase (BTK) is a protein tyrosine kinase that is expressed in B cells, macrophages, and neutrophils. The protein encoded by this gene binds to BTK and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription. This gene has a pseudogene on chromosome 18. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Molecular Weight: 150.528 kDa

Gene ID: 25998

UniProt: Q9P2D0