CMA1 antibody

Catalog No. ABIN6291325

Product Details anti-CMA1 Antibody

Target: CMA1 (Chymase 1, Mast Cell (CMA1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CMA1 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Affinity purification

Immunogen: Recombinant Protein of human CMA1

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000

Comment:

Mast cells in lung, heart, skin and placenta, Expressed in both normal skin and in urticaria pigmentosa lesions

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20C. Avoid freeze / thaw cycles.

Target Details for CMA1

Target: CMA1 (Chymase 1, Mast Cell (CMA1))

Alternative Name: CMA1 (CMA1 Products)

Synonyms: CYH antibody, MCT1 antibody, chymase antibody, MMCP-5 antibody, Mcp-5 antibody, Mcp5 antibody, Mcpt5 antibody, MCP3P antibody, CMA1 antibody, Chymase antibody, chymase 1 antibody, chymase 1, mast cell antibody, chymase-like antibody, CMA1 antibody, Cma1 antibody, LOC100008644 antibody

Background: This gene encodes a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and is thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Alternative splicing results in multiple variants.

Molecular Weight: 27.325 kDa

Gene ID: 1215

UniProt: P23946

Pathways: ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Carbohydrate Homeostasis