CXCR7 antibody

Catalog No. ABIN6291935

Product Details anti-CXCR7 Antibody

Target: CXCR7 (Chemokine (C-X-C Motif) Receptor 7 (CXCR7))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CXCR7 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Affinity purification

Immunogen: A synthetic peptide of human ACKR3

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000

Comment:

Expressed in monocytes, basophils, B-cells, umbilical vein endothelial cells (HUVEC) and B-lymphoblastoid cells, Lower expression detected in CD4+ T-lymphocytes and natural killer cells, In the brain, detected in endothelial cells and capillaries, and in mature neurons of the frontal cortex and hippocampus, Expressed in tubular formation in the kidney, Highly expressed in astroglial tumor endothelial, microglial and glioma cells, Expressed at low levels in normal CD34+ progenitor cells, but at very high levels in several myeloid malignant cell lines, Expressed in breast carcinomas but not in normal breast tissue (at protein level)

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20C. Avoid freeze / thaw cycles.

Target Details for CXCR7

Target: CXCR7 (Chemokine (C-X-C Motif) Receptor 7 (CXCR7))

Alternative Name: ACKR3 (CXCR7 Products)

Synonyms: CMKOR1 antibody, CXC-R7 antibody, CXCR-7 antibody, CXCR7 antibody, GPR159 antibody, RDC-1 antibody, RDC1 antibody, AW541270 antibody, Cmkor1 antibody, Cxcr7 antibody, Rdc1 antibody, ackr3 antibody, cxcr7 antibody, rdc1 antibody, xcxcr7 antibody, atypical chemokine receptor 3 antibody, ORF 74; similar to Kaposi's sarcoma-associated herpesvirus ORF 74 antibody, atypical chemokine receptor 3 L homeolog antibody, ACKR3 antibody, MmrVgp88 antibody, Ackr3 antibody, ackr3.L antibody

Background: This gene encodes a member of the G-protein coupled receptor family. Although this protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP), it is now considered to be an orphan receptor, in that its endogenous ligand has not been identified. The protein is also a coreceptor for human immunodeficiency viruses (HIV). Translocations involving this gene and HMGA2 on chromosome 12 have been observed in lipomas.

Molecular Weight: 41.493 kDa

Gene ID: 57007

UniProt: P25106

Pathways: Myometrial Relaxation and Contraction, Negative Regulation of intrinsic apoptotic Signaling