CIC antibody
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- Target See all CIC Antibodies
- CIC (Capicua Homolog (CIC))
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Reactivity
- Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This CIC antibody is un-conjugated
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Application
- Western Blotting (WB)
- Purification
- Affinity purification
- Immunogen
- Recombinant protein of human CIC
- Isotype
- IgG
- Top Product
- Discover our top product CIC Primary Antibody
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- Application Notes
- WB 1:200 - 1:2000
- Comment
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Expressed in fetal brain
- Restrictions
- For Research Use only
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- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20C. Avoid freeze / thaw cycles.
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- Target
- CIC (Capicua Homolog (CIC))
- Alternative Name
- CIC (CIC Products)
- Synonyms
- wu:fb93c01 antibody, CIC antibody, 1200010B10Rik antibody, mKIAA0306 antibody, capicua transcriptional repressor b antibody, capicua transcriptional repressor antibody, cicb antibody, CIC antibody, Cic antibody
- Background
- The protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID:6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID:21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID:100288687) and FOXO4 (GeneID:4303) have been associated with round cell sarcomas. There are multiple pseudogenes of this gene found on chromosomes 1, 4, 6, 7, 16, 20, and the Y chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms.
- Molecular Weight
- 163.82 kDa
- Gene ID
- 23152
- UniProt
- Q96RK0
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