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HMGCR antibody
HMGCR
Reactivity: Human, Mouse
WB, IHC
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-HMGCR Antibody
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Target
See all HMGCR Antibodies
HMGCR
(3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR))
Reactivity
All reactivities for HMGCR antibodies
Human, Mouse
Host
All hosts for HMGCR antibodies
Rabbit
Clonality
All clonalities for HMGCR antibodies
Polyclonal
Conjugate
All conjugates for HMGCR antibodies
This HMGCR antibody is un-conjugated
Application
All applications for HMGCR antibodies
Western Blotting (WB), Immunohistochemistry (IHC)
Purification
Affinity purification
Immunogen
Recombinant protein of human HMGCR
Isotype
IgG
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Discover our top product HMGCR Primary Antibody
Alternatives
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Application Details
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Application Notes
WB 1:500 - 1:2000 IHC 1:50 - 1:200
Restrictions
For Research Use only
Handling
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Buffer
PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Store at -20C. Avoid freeze / thaw cycles.
Target Details for HMGCR
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Target
HMGCR
(3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR))
Alternative Name
HMGCR (HMGCR Products )
Synonyms
HMGR antibody, LDLCQ3 antibody, hmg-coa-r antibody, HMG-CoAR antibody, Red antibody, 3H3M antibody, BcDNA:LD15354 antibody, CG10367 antibody, Clb antibody, DmHMG-CoAr antibody, Dmel\\CG10367 antibody, HMGCR antibody, HMGCR_Dm antibody, HMGCoAR antibody, HMGCoARr antibody, HMGCoAr antibody, HmG-CoAR antibody, Hmg antibody, bro1 antibody, bs32f05.y1 antibody, clb antibody, hmgc antibody, hmgcr antibody, hmgrc antibody, l(3)01152 antibody, l(3)04684 antibody, hmgcr2 antibody, im:6912716 antibody, zgc:110746 antibody, 3-hydroxy-3-methylglutaryl-CoA reductase antibody, 3-hydroxy-3-methylglutaryl-CoA reductase L homeolog antibody, 3-hydroxy-3-methylglutaryl-Coenzyme A reductase antibody, HMG Coenzyme A reductase antibody, 3-hydroxy-3-methylglutaryl-CoA reductase b antibody, HMGCR antibody, hmgcr.L antibody, Hmgcr antibody, hmgcrb antibody
Background
HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Molecular Weight
97.476 kDa
Gene ID
3156
UniProt
P04035
Pathways
AMPK Signaling , Negative Regulation of Hormone Secretion , Regulation of Lipid Metabolism by PPARalpha
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