SPRY2 antibody

Catalog No. ABIN6293587

Product Details anti-SPRY2 Antibody

Target: SPRY2 (Sprouty Homolog 2 (SPRY2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPRY2 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Affinity purification

Immunogen: A synthetic peptide of human SPRY2

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20C. Avoid freeze / thaw cycles.

Target Details for SPRY2

Target: SPRY2 (Sprouty Homolog 2 (SPRY2))

Alternative Name: SPRY2 (SPRY2 Products)

Synonyms: wu:fk66h11 antibody, wu:fk93e11 antibody, zgc:110440 antibody, hspry2 antibody, xspry2 antibody, sprouty2 antibody, Xsprouty2 antibody, sprouty-2 antibody, Xtsprouty2 antibody, hSPRY2 antibody, sprouty RTK signaling antagonist 2 antibody, sprouty RTK signaling antagonist 2 S homeolog antibody, sprouty homolog 2 (Drosophila) antibody, spry2 antibody, SPRY2 antibody, spry2.S antibody, Spry2 antibody

Background: This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein.

Molecular Weight: 34.688 kDa

Gene ID: 10253

UniProt: O43597

Pathways: EGFR Signaling Pathway, Sensory Perception of Sound, EGFR Downregulation