GBL antibody
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- Target See all GBL Antibodies
- GBL (G protein beta subunit-like (GBL))
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This GBL antibody is un-conjugated
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Application
- Western Blotting (WB)
- Purification
- Affinity purified
- Immunogen
- GBL antibody was raised using a synthetic peptide corresponding to a region with amino acids CAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDSVL
- Top Product
- Discover our top product GBL Primary Antibody
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- Application Notes
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WB: 1 µg/mL
Optimal conditions should be determined by the investigator. - Comment
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GBL Blocking Peptide, catalog no. 33R-1639, is also available for use as a blocking control in assays to test for specificity of this GBL antibody
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Lyophilized powder. Add distilled water for a 1 mg/mL concentration of GBL antibody in PBS
- Concentration
- Lot specific
- Buffer
- PBS
- Handling Advice
- Avoid repeated freeze/thaw cycles.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store at 2-8 °C for short periods. For longer periods of storage, store at -20 °C.
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- Target
- GBL (G protein beta subunit-like (GBL))
- Alternative Name
- GBL (GBL Products)
- Synonyms
- gbl antibody, lts8 antibody, GBL antibody, GbetaL antibody, LST8 antibody, POP3 antibody, WAT1 antibody, 0610033N12Rik antibody, AA409454 antibody, AI505104 antibody, AI851821 antibody, Gbl antibody, fi37e04 antibody, wu:fi37e04 antibody, zgc:55455 antibody, zgc:85668 antibody, MTOR associated protein, LST8 homolog L homeolog antibody, MTOR associated protein, LST8 homolog antibody, MTOR associated protein, LST8 homolog (S. cerevisiae) antibody, mlst8.L antibody, MLST8 antibody, Mlst8 antibody, mlst8 antibody
- Background
- GBL is the subunit of both mTORC1 and mTORC2, which regulate cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino-acids. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin.
- Molecular Weight
- 36 kDa (MW of target protein)
- Pathways
- PI3K-Akt Signaling, RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Actin Filament Polymerization, Autophagy, CXCR4-mediated Signaling Events, BCR Signaling, Warburg Effect
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