DS-PB-00175 recognises Annexin II, a member of a family of structurally related calcium binding proteins implicated in mediating the intracellular action of calcium. Cellular levels of annexin II mRNA and protein are strictly regulated during the mammalian cell cycle with maximal expression as cells enter S-phase.
Supplied as 0.1mg of purified liquid antibody in TBS, containing 0.02% Sodium azide and 0.5% Bovine serum albumin. Its final concentration is 0.5 mg/ml. Please avoid freeze-thaw cycles.
The Annexin family of calcium-binding proteins is composed of at least ten mammalian genes and is characterized by a conserved core domain which binds phospholipids in a Ca2+-dependent manner and a unique amino-terminal region which may confer binding specificity. The interaction between these proteins and biological membranes has led to the hypothesis that they are involved in cellular trafficking processes such as endocytosis, exocytosis and cellular adhesion. Annexin I, alternatively referred to as lipocortin, has been implicated as a mediator of the anti-inflammatory response produced by glucocorticoids and as an inhibitor of cPLA2, a potent mediator of inflammation. Annexin II, also called p36, exists as a monomer or as a heterotetramer, complexed with the S-100-related protein p11. This complex is termed calpactin I. In the tetrameric form, Annexin II is an efficient substrate of PKC family and Src pp60.