MDM2 antibody

Catalog No. ABIN643838

The Mouse Monoclonal anti-MDM2 antibody is suitable to detect MDM2 in samples from Human. It has been validated for IHC (p), IP, IHC (fro) and IHC (rs).

Quick Overview for MDM2 antibody (ABIN643838)

Target: MDM2 (Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MDM2 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Resin Sections) (IHC (rs))

Product Details anti-MDM2 Antibody

Purpose: Mouse Anti-Human MDM2

Specificity: DS-MB-01877 recognizes the 90kD MDM2 protein, which forms a complex with p53 leading to p53 inhibition. DS-MB-01877 also acts to stimulate cell proliferation via its induction of transcription factors such as E2F1 and DPI. It is over expressed in a range of human malignancies, including soft tissue sarcomas, breast cancer and bladder cancer. reacts with: Mouse. Antibody reactivity and working conditions may vary between species.

Characteristics: Transcription and its regulation

Purification: Purified

Immunogen: Synthetic peptide, CSRPSTSSRRRAISE, corresponding to amino acids 154-167 of human MDM2.

Isotype: IgG1

Application Details

Application Notes: Immunohistology - Frozen, Immunoprecipitation, Immunohistology - Paraffin, Immunohistology - Resin

Restrictions: For Research Use only

Handling

Concentration: IgG concentration 1.0 mg/ml

Buffer: Phosphate buffered saline pH7.4

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: -20°C

Target Details for MDM2

Target: MDM2 (Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2))

Alternative Name: MDM2

Pathways: p53 Signaling, PI3K-Akt Signaling, Cell Division Cycle, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Autophagy, Ubiquitin Proteasome Pathway