TRAF6 antibody (TNF Receptor-Associated Factor 6)

Details for Product anti-TRAF6 Antibody No. ABIN6566713
Antigen
Reactivity
Human, Mouse (Murine), Rat (Rattus)
121
71
66
8
7
6
4
3
3
1
1
Host
Rabbit
120
8
2
Clonality
Polyclonal
Conjugate
This TRAF6 antibody is un-conjugated
6
4
3
3
3
3
3
3
3
2
2
2
1
1
1
1
1
Application
Immunofluorescence (IF), Western Blotting (WB)
106
45
35
18
16
13
13
11
3
2
2
2
2
2
1
Options
Immunogen Recombinant protein of human TRAF6
Isotype IgG
Purification Affinity purification
Antigen
Alternative Name TRAF6 (TRAF6 Antibody Abstract)
Background

Synonyms: E3 ubiquitin-protein ligase TRAF6,Interleukin 1 signal transducer,Interleukin-1 signal transducer,MGC 3310,MGC:3310,MGC3310,OTTHUMP00000232772,OTTHUMP00000232773,RING finger protein 85,RNF 85,RNF85,TNF receptor associated factor 6,TNF receptor-associated factor 6,TNF receptor-associated factor 6,E3 ubiquitin protein ligase,TRAF 6,Traf6,TRAF6

Background: The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF receptor superfamily. This protein mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. This protein also interacts with the transforming growth factor (TGF) beta receptor complex and is required for Smad-independent activation of the JNK and p38 kinases. This protein has an amino terminal RING domain which is followed by four zinc-finger motifs, a central coiled-coil region and a highly conserved carboxyl terminal domain, known as the TRAF-C domain. Two alternatively spliced transcript variants, encoding an identical protein, have been reported.

Molecular Weight

Observed_MW: 57kDa

Calculated_MW: 59kDa

Gene ID 7189
UniProt Q9Y4K3
Pathways NF-kappaB Signaling, TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Tube Formation, Hepatitis C, Toll-Like Receptors Cascades
Application Notes WB 1:500 - 1:2000 IF 1:50 - 1:200
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C. Avoid freeze / thaw cycles.
Supplier Images
Image no. 1 for anti-TNF Receptor-Associated Factor 6 (TRAF6) antibody (ABIN6566713) Western blot analysis of extracts of various cell lines, using TRAF6 antibody.
Image no. 2 for anti-TNF Receptor-Associated Factor 6 (TRAF6) antibody (ABIN6566713) Immunofluorescence analysis of HeLa cells using TRAF6 antibody.