CACNA2D2 antibody (Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 2)

Details for Product anti-CACNA2D2 Antibody No. ABIN6566845
Antigen
Reactivity
Mouse (Murine), Rat (Rattus)
44
30
14
2
2
1
1
Host
Rabbit
37
10
Clonality
Polyclonal
Conjugate
This CACNA2D2 antibody is un-conjugated
3
2
2
2
2
2
1
1
1
1
1
1
Application
Western Blotting (WB)
42
27
26
9
7
3
1
1
Options
Immunogen Recombinant protein of human CACNA2D2
Isotype IgG
Purification Affinity purification
Antigen
Alternative Name CACNA2D2 (CACNA2D2 Antibody Abstract)
Background

Synonyms: Alpha 2 delta calcium channel subunit,CA2D2,CACNA2D,Cacna2d2,Calcium channel,voltage-dependent,alpha 2/delta subunit 2,Calcium channel,voltage-dependent,alpha 2/delta subunit 2 gene 26,Calcium voltage gated channel auxiliary subunit alpha2delta 2,Gene 26,KIAA0558,LUAC11.1,Voltage-dependent calcium channel subunit alpha-2/delta-2,Voltage-dependent calcium channel subunit delta-2,Voltage-gated calcium channel subunit alpha-2/delta-2

Background: Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization. This gene encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex. The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2/delta, beta, and gamma. The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation/inactivation kinetics. The subunit encoded by this gene undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide. This subunit is a receptor for the antiepileptic drug, gabapentin. Mutations in this gene are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in this gene are correlated with increased sensitivity to opioid drugs. Alternative splicing results in multiple transcript variants encoding different isoforms.

Molecular Weight

Observed_MW: 140kDa

Calculated_MW: 122kDa/129kDa/130kDa

Gene ID 9254
UniProt Q9NY47
Pathways Skeletal Muscle Fiber Development
Application Notes WB 1:200 - 1:2000
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C. Avoid freeze / thaw cycles.
Supplier Images
Image no. 1 for anti-Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 2 (CACNA2D2) antibody (ABIN6566845) Western blot analysis of extracts of various cell lines, using CACNA2D2 antibody.