TDP1 antibody

Catalog No. ABIN6569761

Product Details anti-TDP1 Antibody

Target: TDP1 (Tyrosyl-DNA Phosphodiesterase 1 (TDP1))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TDP1 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Affinity purification

Immunogen: Recombinant protein of human TDP1

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for TDP1

Target: TDP1 (Tyrosyl-DNA Phosphodiesterase 1 (TDP1))

Alternative Name: TDP1 (TDP1 Products)

Synonyms: 2810481F14Rik antibody, 4921509N21Rik antibody, AI838772 antibody, AW493413 antibody, E430034L06Rik antibody, MLZ-501 antibody, SCAN1 antibody, tdp1 antibody, MGC83708 antibody, TDP1 antibody, F8M21.60 antibody, F8M21_60 antibody, tyrosyl-DNA phosphodiesterase 1 antibody, tyrosyl-DNA phosphodiesterase 1 antibody, tyrosyl-DNA Phosphodiesterase (Tdp1) antibody, tyrosyl-DNA phosphodiesterase 1 L homeolog antibody, tyrosyl-DNA phosphodiesterase-like protein antibody, TDP1 antibody, Tc00.1047053511191.10 antibody, Tdp1 antibody, tdp1.L antibody, tdp1 antibody, PTRG_11198 antibody, MCYG_02121 antibody, MGYG_03035 antibody

Background:

Synonyms: AI838772,AW493413,FLJ11090,MGC104252,MGC112732,RP24-311F12.2,SCAN1,TDP1,TYDP,TYDP1,Tyr-DNA phosphodiesterase 1,Tyrosyl-DNA phosphodiesterase 1

Background: The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1).

Molecular Weight:

Observed_MW: 70kDa

Calculated_MW: 41kDa/68kDa

Gene ID: 55775

UniProt: Q9NUW8