NCOR2 antibody

Catalog No. ABIN6571720

Product Details anti-NCOR2 Antibody

Target: NCOR2 (Nuclear Receptor Co-Repressor 2 (NCOR2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NCOR2 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Affinity purification

Immunogen: Recombinant protein of human NCOR2

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for NCOR2

Target: NCOR2 (Nuclear Receptor Co-Repressor 2 (NCOR2))

Alternative Name: NCOR2 (NCOR2 Products)

Synonyms: CTG26 antibody, N-CoR2 antibody, SMAP270 antibody, SMRT antibody, SMRTE antibody, SMRTE-tau antibody, TNRC14 antibody, TRAC antibody, TRAC-1 antibody, TRAC1 antibody, N-CoR antibody, SMRTe antibody, NCOR2 antibody, gb:be017685 antibody, si:bz71m17.2 antibody, smrt antibody, ctg26 antibody, smrte antibody, trac1 antibody, tnrc14 antibody, trac-1 antibody, smrte-tau antibody, nuclear receptor corepressor 2 antibody, nuclear receptor co-repressor 2 antibody, NCOR2 antibody, Ncor2 antibody, ncor2 antibody

Background:

Synonyms: CTG 26,CTG repeat protein 26,CTG26,N CoR2,N-CoR2,NCoR 2,Ncor2,NCOR2,Nuclear Receptor Co-Repressor 2,Nuclear receptor corepressor 2,retinoic-acid-receptor-associated corepressor,Silencing Mediator for Retanoid and Thyroid Hormone Receptors,Silencing mediator of retinoic acid and thyroid hormone receptor,SMAP 270,SMAP270,SMRT,SMRTE,SMRTE tau,T3 receptor associating factor,T3 receptor-associating factor,Thyroid retinoic acid receptor associated corepressor,Thyroid-,TNRC 14,TNRC14,TRAC 1,TRAC,TRAC1

Background: This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.

Molecular Weight:

Observed_MW: 180kDa

Calculated_MW: 81kDa/268kDa/273kDa/274kDa

Gene ID: 9612

UniProt: Q9Y618

Pathways: Notch Signaling, Carbohydrate Homeostasis, Chromatin Binding, Regulation of Lipid Metabolism by PPARalpha