SETD8 antibody (C-Term, N-Term)

Catalog No. ABIN6655982

Product Details anti-SETD8 Antibody

Target: SETD8 (SET Domain Containing (Lysine Methyltransferase) 8 (SETD8))

Binding Specificity: C-Term, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SETD8 antibody is un-conjugated

Application: Western Blotting (WB)

Cross-Reactivity: Human, Mouse (Murine)

Cross-Reactivity (Details): Cross reactivity with SETD8 from species other than human and mouse not tested.

Purification: Anti-SETD8 Antibody is monospecific antiserum processed by delipidation and defibrination followed by sterile filtration.

Immunogen:

Immunogen: Anti-SETD8 Antibody was produced in rabbits by repeated immunizations of the full length human SETD8 protein containing a Flag-tagged N-terminus and a His-tagged C terminus.

Immunogen Type: Recombinant Protein

Application Details

Application Notes:

Application Note: Anti-SETD8 Antibody is suitable for Western Blots. Specific conditions for reactivity should be optimized by the end user.  Expect a band approximately 40 kDa in the appropriate cell lysate or extract.

Western Blot Dilution: 1:1,000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer:

0.01 % (w/v) Sodium Azide

Stabilizer: None

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: RT,4 °C,-20 °C

Storage Comment: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Target Details for SETD8

Target: SETD8 (SET Domain Containing (Lysine Methyltransferase) 8 (SETD8))

Alternative Name: SETD8 (SETD8 Products)

Synonyms: KMT5A antibody, PR-Set7 antibody, SET07 antibody, SET8 antibody, 2410195B05Rik antibody, AA617402 antibody, AW536475 antibody, PR-SET7 antibody, setd8b antibody, wu:fc23f12 antibody, zgc:171649 antibody, Pr-set7 antibody, RGD1305893 antibody, Setd8 antibody, kmt5a antibody, kmt5a-a antibody, setd8 antibody, setd8-a antibody, set8a antibody, setd8a antibody, wu:fj33f02 antibody, zgc:153719 antibody, lysine methyltransferase 5A antibody, lysine methyltransferase 5Ab antibody, lysine methyltransferase 5A S homeolog antibody, lysine methyltransferase 5Aa antibody, KMT5A antibody, Kmt5a antibody, kmt5ab antibody, kmt5a.S antibody, kmt5aa antibody

Background:

Synonyms: N-lysine methyltransferase SETD8, H4-K20-HMTase SETD8, Histone-lysine N-methyltransferse SETD8, Lysine N-methyltransferase 5A, PR/SET domain-containing protein 07, SET domain-containing protein 8, PR-Set7, PR/SET07

Background: SETD8 is a histone methyl transferase that specifically monomethylates 'Lys-20' of histone H4. This histone modification represents a specific tag for epigenetic transcriptional repression and is enriched during mitosis. SETD8 may also play a role in maintaining silet chromatin by preventing the acetylation of the H4 tail. Anti-SETD8 Antibody is ideal for research in Gene Expression, Epigenetics and Chromatin Remodeling.

Gene Name: SETD8

Gene ID: 387893

NCBI Accession: NP_065115

UniProt: Q9NQR1