CACNB2 antibody (AA 551-655)

Catalog No. ABIN682633

Product Details anti-CACNB2 Antibody

Target: CACNB2 (Calcium Channel, Voltage-Dependent, beta 2 Subunit (CACNB2))

Binding Specificity: AA 551-655

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CACNB2 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Predicted Reactivity: Human,Mouse,Rat,Dog,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CACNB2

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for CACNB2

Target: CACNB2 (Calcium Channel, Voltage-Dependent, beta 2 Subunit (CACNB2))

Alternative Name: CACNB2 (CACNB2 Products)

Synonyms: CACNLB2 antibody, CAVB2 antibody, MYSB antibody, AW060387 antibody, CAB2 antibody, Cavbeta2 antibody, Cchb2 antibody, Cacnlb2 antibody, Cacnb2 antibody, CACNB2 antibody, CACNB2.2 antibody, cacnb2a antibody, im:7141271 antibody, si:dkey-32m20.2 antibody, calcium voltage-gated channel auxiliary subunit beta 2 antibody, calcium channel, voltage-dependent, beta 2 subunit antibody, calcium channel, voltage-dependent, beta 2b antibody, CACNB2 antibody, Cacnb2 antibody, cacnb2b antibody

Background:

Synonyms: Voltage-dependent L-type calcium channel subunit beta-2, CAB2, Cacnb2, Cacnlb2, VDCC-L Beta, Calcium channel voltage-dependent subunit beta 2, calcium channel, voltage-dependent, beta 2 subunit, calcium channel beta 2c subunit, calcium channel L-type beta 2 subunit, CACB2_HUMAN.

Background: CACNB2 is a subunit of a voltage-dependent calcium channel protein which is a member of the voltage-gated calcium channel superfamily, expressed in the CNS. The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. It was originally identified as an antigen target in Lambert-Eaton myasthenic syndrome which is an autoimmune disorder. Mutations in this gene are associated with Brugada symdrome. Alternatively spliced variants have been identified for this gene.

Gene ID: 783

Pathways: Skeletal Muscle Fiber Development