Complement 3d (C3d) (Acute Humoral Rejection Marker) antibody
Reactivity: Human
Coat, ELISA
Host: Mouse
Monoclonal
C3D-2891
unconjugated
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- Target
- Complement 3d (C3d) (Acute Humoral Rejection Marker)
- Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- Un-conjugated
- Application
- Coating (Coat), ELISA
- Purification
- Purified by Protein A/G
- Immunogen
- Recombinant full-length human Complement C3 protein
- Clone
- C3D-2891
- Isotype
- IgG2b kappa
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anti-Complement 3d (C3d) (Acute Humoral Rejection Marker) antibody
Reactivity: Human Coat, ELISA Host: Mouse Monoclonal C3D-2891 unconjugated
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- Application Notes
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Positive Control: Human kidney or rejected renal transplant tissue.
Known Application: ELISA (For coating, order Ab without BSA), Optimal dilution for a specific application should be determined.
- Restrictions
- For Research Use only
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- Concentration
- 200 μg/mL
- Buffer
- 10 mM PBS with 0.05 % BSA & 0.05 % azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-80 °C
- Storage Comment
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Expiry Date
- 24 months
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- Target
- Complement 3d (C3d) (Acute Humoral Rejection Marker)
- Background
- The complement component proteins, C2, C3, C4 and C5, are potent anaphylatoxins that are released during complement activation. Binding of these proteins to their respective G protein-coupled receptors, C3aR, C1R and C5aR, induces proinflammatory events, such as cellular degranulation, smooth muscle contraction, arachidonic acid metabolism, cytokine release, leukocyte activation and cellular chemotaxis. C3d is a terminal degradation product of C3 that plays an important role in modulation of the adaptive immune response through the interaction with complement receptor type 2 (CR2). CR2 is important in the switched-isotype, high-affinity and memory humoral immune responses to T-dependent foreign antigens, as well as in the development of the natural antibody repertoire. This pH - and ionic strength-dependent association of C3d with CR2 represents a link between innate and adaptive immunity.
- Molecular Weight
- 35kDa (predicted)
- Gene ID
- 718
- UniProt
- P01024
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