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MUC16 antibody

CA125 Reactivity: Human IHC (f) Host: Mouse Monoclonal MUC16-1860 unconjugated
Catalog No. ABIN6936546
  • Target See all MUC16 (CA125) Antibodies
    MUC16 (CA125) (Mucin 16, Cell Surface Associated (CA125))
    Reactivity
    • 80
    • 9
    • 4
    Human
    Host
    • 56
    • 30
    • 2
    • 1
    Mouse
    Clonality
    • 46
    • 43
    Monoclonal
    Conjugate
    • 43
    • 14
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This MUC16 antibody is un-conjugated
    Application
    • 56
    • 38
    • 25
    • 16
    • 13
    • 13
    • 9
    • 9
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
    Specificity
    The mucins are a family of highly glycosylated, secreted proteins with a basic structure consisting of a variable number of tandem repeats (VNTRs). Membrane-associated and secretory Mucins are high molecular weight glycoproteins of the glycocalyx (polysaccharide biofilm) that protects mucosal epithelium from particulate matter and microorganisms. Epithelial Mucins are large, secreted and cell surface glycoproteins crucial for adhesion modulation, signaling and epithelial cell protection. The number of repeats is highly polymorphic and varies among different alleles. The Mucin family consists of Mucins 1-4, Mucin 5 (AC and B), Mucins 6-8, Mucins 11-13 and Mucins 15-17. The Mucin 16 protein (also commonly referred to as CA125), encoded for by the gene MUC16, is a very high molecular weight tumor antigen consisting of three domains: a carboxy terminal domain, an extracellular domain and an amino terminal domain. Mucin 16, an ovarian cancer-associated antigen, is used as a marker to monitor the progress of epithelial ovarian cancer. It is a hydrophilic membrane-associated protein that may be involved in vitamin A functions.
    Cross-Reactivity (Details)
    Human.
    Purification
    1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
    Immunogen
    Full length native MUC16 protein Purified from human ovarian carcinoma
    Clone
    MUC16-1860
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product CA125 Primary Antibody
  • Application Notes

    Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

    Positive_Control: MDA-MB-468 cells. Ovarian Cancer.

    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    Prepared in 10 mM PBS, WITHOUT BSA and Azide.
    Preservative
    Azide free
    Storage
    -20 °C,-80 °C
    Storage Comment
    Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
    Expiry Date
    24 months
  • Target
    MUC16 (CA125) (Mucin 16, Cell Surface Associated (CA125))
    Alternative Name
    CA125 (CA125 Products)
    Synonyms
    CA125 antibody, 1110008I14Rik antibody, Ca125 antibody, Gm1480 antibody, RGD1308422 antibody, MUC16 antibody, mucin 16, cell surface associated antibody, mucin 16 antibody, mucin-16 antibody, MUC16 antibody, Muc16 antibody, LOC476718 antibody, LOC712735 antibody
    Background
    CA125, Cancer antigen 125, MUC16, Mucin16, Ovarian cancer-related tumor marker CA125, Ovarian carcinoma antigen CA125,MUC16 / CA125 (Ovarian Carcinoma Marker)
    Cellular localisation: Cell Surface and Secreted
    Molecular Weight
    >2,000kDa
    Gene ID
    94025, 432676
    UniProt
    Q8WXI7
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