Recombinant CD1a antibody
-
- Target See all CD1a Antibodies
- CD1a
- Antibody Type
- Recombinant Antibody
-
Reactivity
- Human
-
Host
- Rabbit
-
Clonality
- Monoclonal
-
Conjugate
- This CD1a antibody is un-conjugated
-
Application
- Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- Specificity
- At least five CD1 genes (CD1a, b, c, d, and e) are identified. CD1 proteins have been demonstrated to restrict T cell response to non-peptide lipid and glycolipid antigens and play a role in non-classical antigen presentation. CD1a is a non-polymorphic MHC Class 1 related cell surface glycoprotein, expressed in association with Beta-2 microglobulin. Anti-CD1a labels Langerhans cell histiocytosis (Histiocytosis X), extranodal histiocytic sarcoma, a subset of T-lymphoblastic lymphoma/leukemia, and interdigitating dendritic cell sarcoma of the lymph node. When combined with antibodies against TTF-1 and CD5, anti-CD1a is useful in distinguishing between pulmonary and thymic neoplasms since CD1a is consistently expressed in thymic lymphocytes in both typical and atypical thymomas, but only focally in 1/6 of thymic carcinomas and not in lymphocytes in pulmonary neoplasms. Anti-CD1a is reported to be a new marker for perivascular epithelial cell tumor (PEComa).
- Cross-Reactivity (Details)
- Human.
- Purification
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogen
- Recombinant full-length human CD1a protein
- Clone
- C1A-1506R
- Isotype
- IgG
- Top Product
- Discover our top product CD1a Primary Antibody
-
-
- Application Notes
-
Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.
Positive_Control: MOLT-4 cells. Paracortex in a tonsil or a reactive lymph node.
- Restrictions
- For Research Use only
-
- Concentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Preservative
- Azide free
- Storage
- -20 °C,-80 °C
- Storage Comment
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Expiry Date
- 24 months
-
- Target
- CD1a
- Alternative Name
- CD1A (CD1a Products)
- Synonyms
- CD1 antibody, FCB6 antibody, HTA1 antibody, R4 antibody, T6 antibody, CD1A antibody, CD1a molecule antibody, CD1 antigen antibody, T-cell surface glycoprotein CD1a antibody, CD1A antibody, CD1.1 antibody, LOC100156095 antibody, LOC101111409 antibody
- Background
-
Cortical thymocyte antigen CD1A, Epidermal dendritic cell marker CD1a antibody, FCB6, HTA1, T cell surface antigen T6 / Leu 6, T-Cell Surface Glycoprotein CD1A,CD1a / HTA1 (Mature Langerhans Cells Marker)
Cellular localisation: Cell Surface and Cytoplasmic - Molecular Weight
- 49kDa
- Gene ID
- 909, 1309
- UniProt
- P06126
- Pathways
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
-