CD1c antibody
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- Target See all CD1c (CD1C) Antibodies
- CD1c (CD1C) (T-cell surface glycoprotein CD1c (CD1C))
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This CD1c antibody is un-conjugated
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Application
- ELISA, Coating (Coat)
- Specificity
- The CD1 multigene family encodes five forms of the CD1 T-cell surface glycoprotein in human, designated CD1A, 1B, 1C, 1D and 1E. CD1, a type 1 membrane protein, has structural similarity to the MHC class I antigen and has been shown to present lipid antigens for recognition by T lymphocytes. CD1 antigens are associated with -2-Microglobulin and expressed on cortical thymocytes, Langerhans cells, a B cell subset and some dendritic cells. Specifically, CD1A is a marker for Langerhans cell histiocytosis (LCH) and is found on interdigitating cells. Adaptor-protein complexes and CD1-associated chaperones control CD1 trafficking, and the development and activation of CD1-restricted T cells. Constitutive endocytosis of CD1B molecules and the differential sorting of MHC class II from lysosomes separate peptide- and lipid antigen-presenting molecules during dendritic cell maturation. CD1B is also expressed in interdigitating cells. The human CD1 genes are all closely linked in a cluster mapping at chromosome 1q23.1
- Cross-Reactivity (Details)
- Human.
- Purification
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogen
- Recombinant full-length human CD1c protein
- Clone
- CD1C-1603
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product CD1C Primary Antibody
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- Application Notes
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Known_Application: ELISA (For coating, order Ab without BSA), Optimal dilution for a specific application should be determined.
Positive_Control: Expressed on cortical thymocytes, on certain T-cell leukemias and in various other tissues.
- Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Preservative
- Azide free
- Storage
- -20 °C,-80 °C
- Storage Comment
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Expiry Date
- 24 months
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- Target
- CD1c (CD1C) (T-cell surface glycoprotein CD1c (CD1C))
- Alternative Name
- CD1C (CD1C Products)
- Synonyms
- BDCA1 antibody, CD1 antibody, CD1A antibody, R7 antibody, CD1c molecule antibody, CD1C antibody
- Background
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BDCA1, CD1, CD1A, CD1c, CD1C antigen c polypeptide, CD1c molecule, Cortical thymocyte antigen CD1C, Differentiation antigen CD1 alpha 3, R7, T cell surface glycoprotein CD1c,CD1c
Cellular localisation: Cell Surface - Molecular Weight
- 43kDa
- Gene ID
- 911, 132448
- UniProt
- P29017
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