Recombinant Transferrin Receptor antibody (Extracellular Domain)
-
- Target See all Transferrin Receptor (TFRC) Antibodies
- Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))
- Antibody Type
- Recombinant Antibody
-
Binding Specificity
- AA 94-212, Extracellular Domain
-
Reactivity
- Human
-
Host
- Rabbit
-
Clonality
- Monoclonal
-
Conjugate
- This Transferrin Receptor antibody is un-conjugated
-
Application
- Immunohistochemistry (IHC), Staining Methods (StM)
- Specificity
- It recognizes a ~90-95 kDa protein which is identified as cell surface transferrin receptor (CD71), a disulfide-bonded homodimeric glycoprotein of 180-190 kDa. This MAb is highly specific to CD71 and shows no cross-reaction with other related proteins. Ligand for transferrin receptor is the serum iron transport protein, transferrin. This receptor is broadly distributed in carcinomas, sarcomas, leukemias, and lymphomas. CD71/Transferrin receptor has been reported to be associated with cell proliferation in both normal and neoplastic tissues and useful in predicting clinical behavior or response to therapy in a number of malignancies including breast cancer.
- Purification
- Purified by Protein A/G
- Immunogen
- Recombinant human extracellular TFRC protein fragment (aa94-212) (exact sequence is proprietary)
- Clone
- TFRC-2898R
- Isotype
- IgG
- Top Product
- Discover our top product TFRC Primary Antibody
-
-
- Application Notes
-
Positive Control: Jurkat, HeLa, MCF-7 or K562 cells. Human placenta or Bone Marrow.
Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes) Optimal dilution for a specific application should be determined.
- Restrictions
- For Research Use only
-
- Buffer
- 10 mM PBS without BSA and without Azide.
- Preservative
- Azide free
- Storage
- 4 °C,-80 °C
- Storage Comment
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months.
- Expiry Date
- 24 months
-
- Target
- Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))
- Alternative Name
- CD71 / Transferrin Receptor (TFRC) (TFRC Products)
- Synonyms
- Trfr antibody, LOC100219280 antibody, tfr antibody, cd71 antibody, tfr1 antibody, trfr antibody, CD71 antibody, T9 antibody, TFR antibody, TFR1 antibody, TR antibody, TRFR antibody, p90 antibody, 2610028K12Rik antibody, AI195355 antibody, AI426448 antibody, AU015758 antibody, E430033M20Rik antibody, Mtvr-1 antibody, Mtvr1 antibody, transferrin receptor antibody, TFRC antibody, Tfrc antibody, tfrc antibody
- Molecular Weight
- 85-95kDa (monomer), 190kDa (dimer)
- Gene ID
- 7037
- UniProt
- P02786
- Pathways
- Transition Metal Ion Homeostasis
-