CDX2 antibody (AA 150-249)
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- Target See all CDX2 Antibodies
- CDX2 (Caudal Type Homeobox 2 (CDX2))
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Binding Specificity
- AA 150-249
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This CDX2 antibody is un-conjugated
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Application
- ELISA, Coating (Coat), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Immunostaining (ISt)
- Specificity
- The intestine-specific transcription factors CDX1 and CDX2 are important for directing intestinal development, differentiation, proliferation and maintenance of the intestinal phenotype. CDX2 protein expression has been seen in GI carcinomas. Anti-CDX2 has been useful to establish GI origin of metastatic adenocarcinomas and carcinoidsand is especially useful to distinguish metastatic colorectal adenocarcinoma from lung adenocarcinoma.However, mucinous carcinomas of the ovary also express CDX2 protein. It limits the usefulness of this marker in the distinction of metastatic colorectal adenocarcinoma from mucinous carcinoma of the ovary.
- Cross-Reactivity (Details)
- Human.
- Purification
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogen
- Recombinant fragment (around aa150-249) of human CDX2 protein (exact sequence is proprietary)
- Clone
- CDX2-1690
- Isotype
- IgG2a kappa
- Top Product
- Discover our top product CDX2 Primary Antibody
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- Application Notes
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Known_Application: ELISA (Use Ab at 2-4 μg/mL for coating) (Order Ab without BSA), ,Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 min at RT),(Staining of formalin-fixed tissues is enhanced by heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0 for 45 min at 95°C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.
Positive_Control: HT29 cells. Colon Carcinoma.
- Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Preservative
- Azide free
- Storage
- -20 °C,-80 °C
- Storage Comment
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Expiry Date
- 24 months
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- Target
- CDX2 (Caudal Type Homeobox 2 (CDX2))
- Alternative Name
- CDX2 (CDX2 Products)
- Synonyms
- CDX2 antibody, MGC130987 antibody, cdx3-like antibody, CDX-3 antibody, CDX3 antibody, CDX-2 antibody, Cdx-2 antibody, caudal type homeobox 2 antibody, caudal type homeobox 2 L homeolog antibody, caudal type homeo box 2 antibody, CDX2 antibody, cdx2.L antibody, Cdx2 antibody
- Background
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Caudal type homeobox 2, Caudal type homeobox transcription factor 2, Caudal-type homeobox protein 2, CDX2,CDX2 / Caudal Type Homeobox 2 (GI Epithelial Marker)
Cellular localisation: Nuclear - Molecular Weight
- 40kDa
- Gene ID
- 1045, 174249
- UniProt
- Q99626
- Pathways
- Peptide Hormone Metabolism, Stem Cell Maintenance
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