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Complement 3d (C3d) (Acute Humoral Rejection Marker) antibody

Reactivity: Human Coat, ELISA Host: Mouse Monoclonal C3D-2891 unconjugated
Catalog No. ABIN6937012
  • Target
    Complement 3d (C3d) (Acute Humoral Rejection Marker)
    Reactivity
    Human
    Host
    • 1
    Mouse
    Clonality
    • 1
    Monoclonal
    Conjugate
    • 1
    Un-conjugated
    Application
    Coating (Coat), ELISA
    Purification
    Purified by Protein A/G
    Immunogen
    Recombinant full-length human Complement C3 protein
    Clone
    C3D-2891
    Isotype
    IgG2b kappa
  • Application Notes

    Positive Control: Human kidney or rejected renal transplant tissue.

    Known Application: ELISA (For coating, order Ab without BSA), Optimal dilution for a specific application should be determined.

    Restrictions
    For Research Use only
  • Buffer
    10 mM PBS without BSA and without Azide.
    Preservative
    Azide free
    Storage
    4 °C,-80 °C
    Storage Comment
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months.
    Expiry Date
    24 months
  • Target
    Complement 3d (C3d) (Acute Humoral Rejection Marker)
    Background
    The complement component proteins, C2, C3, C4 and C5, are potent anaphylatoxins that are released during complement activation. Binding of these proteins to their respective G protein-coupled receptors, C3aR, C1R and C5aR, induces proinflammatory events, such as cellular degranulation, smooth muscle contraction, arachidonic acid metabolism, cytokine release, leukocyte activation and cellular chemotaxis. C3d is a terminal degradation product of C3 that plays an important role in modulation of the adaptive immune response through the interaction with complement receptor type 2 (CR2). CR2 is important in the switched-isotype, high-affinity and memory humoral immune responses to T-dependent foreign antigens, as well as in the development of the natural antibody repertoire. This pH - and ionic strength-dependent association of C3d with CR2 represents a link between innate and adaptive immunity.
    Molecular Weight
    35kDa (predicted)
    Gene ID
    718
    UniProt
    P01024
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