FLT1 antibody

Catalog No. ABIN6937237

Product Details anti-FLT1 Antibody

Target: FLT1 (Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This FLT1 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunofluorescence (IF), Functional Studies (Func)

Specificity: Three cell membrane receptor tyrosine kinases, Flt-1 (also designated VEGF-R1), Flk-1 (also designated VEGF-R2) and Flt-4, putatively involved in the growth of endothelial cells, are characterized by the presence of seven immunoglobulin-like sequences in their extracellular domain. These receptors exhibit high degrees of sequence relatedness to each other as well as lesser degrees of relatedness to the class III receptors including CSF-1/Fms, PDGR, SLFR/Kit and Flt-3/Flk-2. Two members of this receptor class, Flt-1 and Flk-1, have been shown to represent high affinity receptors for vascular endothelial growth factors (VEGFs). On the basis of structural similarity to Flt-1 and Flk-1, it has been speculated that Flt-4 might represent a third receptor for either VEGF or a VEGF-related ligand.

Cross-Reactivity (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant human VEGF-R1 protein

Clone: FLT1-658

Isotype: IgG1 kappa

Application Details

Application Notes:

Known_Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Functional Studies (Order Ab without BSA & Azide), Optimal dilution for a specific application should be determined.

Positive_Control: 293FT or A431 cells. Cerebellum or skin cancer.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Expiry Date: 24 months

Target Details for FLT1

Target: FLT1 (Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1))

Alternative Name: FLT1 (FLT1 Products)

Synonyms: FLT antibody, FLT-1 antibody, VEGFR-1 antibody, VEGFR1 antibody, FLT1 antibody, flt1b antibody, sFlt1 antibody, AI323757 antibody, Flt-1 antibody, fms related tyrosine kinase 1 antibody, FMS-related tyrosine kinase 1 antibody, vascular endothelial growth factor receptor 1 antibody, fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) antibody, FMS-like tyrosine kinase 1 antibody, vascular endothelial growth factor receptor-1 antibody, FLT1 antibody, Flt1 antibody, CpipJ_CPIJ012087 antibody, flt1 antibody, FLT-1 antibody

Background: Fms like tyrosine kinase 1 (Flt-1), Fms-like tyrosine kinase 1, FRT, Tyrosine protein kinase FRT, Tyrosine protein kinase receptor FLT, Vascular endothelial growth factor receptor 1 (VEGFR1), Vascular permeability factor receptor 1,VEGF-R1 / FLT-1
Cellular localisation: Cell surface

Molecular Weight: 150-180kDa

Gene ID: 2321, 594454

UniProt: P17948

Pathways: RTK Signaling, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals