HIV-1 p24 antibody

Catalog No. ABIN6937461

Product Details anti-HIV-1 p24 Antibody

Target: HIV-1 p24 (Human Immunodeficiency Virus 1 Capsid (HIV-1 p24))

Reactivity: Human Immunodeficiency Virus (HIV)

Host: Mouse

Clonality: Monoclonal

Conjugate: This HIV-1 p24 antibody is un-conjugated

Application: ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC), Coating (Coat)

Purification: Purified by Protein A/G

Immunogen: Recombinant HIV-1 Gag p24 protein

Clone: HIV1-24-661

Isotype: IgG1 kappa

Application Details

Application Notes:

Positive Control: HIV-1 infected cells. Tissues.

Known Application: ELISA (For coating, order Ab without BSA), Immunocytochemistry (Acetone or paraformaldehyde fixed) (0.5-1 μg/mL for 30 min), Immunofluorescence (0.5-1 μg/mL), Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Handling

Buffer: 10 mM PBS without BSA and without Azide.

Preservative: Azide free

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody is stable for 24 months.

Expiry Date: 24 months

Target Details for HIV-1 p24

Target: HIV-1 p24 (Human Immunodeficiency Virus 1 Capsid (HIV-1 p24))

Alternative Name: Human Immunodeficiency Virus Type-1 p24 (HIV1-p24) (HIV-1 p24 Products)

Target Type: Viral Protein

Background: Human immunodeficiency virus (HIV) is a retrovirus that causes acquired immune deficiency syndrome (AIDS), a condition in humans in which the immune system begins to fail, leading to life-threatening opportunistic infections. HIV mainly infects vital cells in the human immune system such as helper T cells (specifically CD4+ T cells), macrophages and dendritic cells. Two species of HIV infect humans: HIV-1 and HIV-2, with HIV-1 being the more virulent strain. The gag gene of human immunodeficiency virus 1 (HIV-1) encodes a precursor protein known as Pr55Gag. The viral protease PR cleaves this precursor to generate p17, p24, p7, and p6 proteins, which are required for virus particle assembly. HIV-1 Gag p24 is a capsid protein that constitutes the core of AIDS virus HIV-1. p6 and p7 are the components of the nucleocapsid, and p17 provides a protective matrix. HIV-1 Gag p24 is indispensable to the reproduction of AIDS virus and constitutes an essential element for the AIDS virus particle construction. As this protein is detectable from the early stage of AIDS virus infection, its measurement is commonly used as an indicator of HIV-1 infection and viral load.

Molecular Weight: 24kDa (mature), 55kDa & 41kDa (precursors)

Gene ID: 155348

UniProt: P04585