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Recombinant PTGS2 antibody (AA 442-572)

PTGS2 Reactivity: Human IHC, IHC (f) Host: Rabbit Monoclonal COX2-3232R unconjugated Recombinant Antibody
Catalog No. ABIN6938254
  • Target See all PTGS2 Antibodies
    PTGS2 (Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2))
    Antibody Type
    Recombinant Antibody
    Binding Specificity
    • 16
    • 15
    • 11
    • 7
    • 7
    • 6
    • 6
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 442-572
    Reactivity
    • 107
    • 55
    • 45
    • 21
    • 5
    • 2
    • 2
    • 1
    • 1
    Human
    Host
    • 95
    • 19
    • 2
    Rabbit
    Clonality
    • 94
    • 22
    Monoclonal
    Conjugate
    • 60
    • 9
    • 7
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PTGS2 antibody is un-conjugated
    Application
    • 97
    • 39
    • 35
    • 27
    • 27
    • 26
    • 22
    • 19
    • 14
    • 11
    • 8
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
    Specificity
    Prostaglandins are a diverse group of autocrine and paracrine hormones that mediate many cellular and physiologic processes. Prostaglandin H2 (PGH2) is an intermediate molecule in formation of the prostaglandins. Cyclooxygenase-1 (Cox-1) and cyclooxygenase-2 (Cox-2) are prostaglandin synthases that catalyze the formation of PGH2 from arachidonic acid (AA). Cox-1 and Cox-2 are isozymes of prostaglandin-endoperoxidase synthase (PTGS). Cox-1 is constitutively expressed in most tissues and is thought to serve in general housekeeping functions. Cox-2 is efficiently induced in migratory cells responding to pro-inflammatory stimuli and is considered to be an important mediator of inflammation. Both enzymes are targets for the nonsteroidal therapeutic anti-inflammatory drugs, NSAIDs. COX2 expression is significantly increased in 85-90 % of human colorectal adenocarcinomas whereas levels of COX-1 are not changed.
    Cross-Reactivity (Details)
    Human.
    Purification
    1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
    Immunogen
    Recombinant human COX2 protein fragment (around aa 442-572) (exact sequence is proprietary)
    Clone
    COX2-3232R
    Isotype
    IgG
    Top Product
    Discover our top product PTGS2 Primary Antibody
  • Application Notes

    Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

    Positive_Control: Human colon or lung carcinoma tissue (IHC).

    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    Prepared in 10 mM PBS, WITHOUT BSA and Azide.
    Preservative
    Azide free
    Storage
    -20 °C,-80 °C
    Storage Comment
    Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
    Expiry Date
    24 months
  • Target
    PTGS2 (Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2))
    Alternative Name
    PTGS2 (PTGS2 Products)
    Synonyms
    COX-2 antibody, COX2 antibody, GRIPGHS antibody, PGG/HS antibody, PGHS-2 antibody, PHS-2 antibody, hCox-2 antibody, Cox-2 antibody, Pghs2 antibody, TIS10 antibody, Cox2 antibody, cox-2 antibody, CEF147 antibody, PGHS2 antibody, PHSII antibody, cox2 antibody, gripghs antibody, pgg/hs antibody, pghs-2 antibody, phs-2 antibody, PTGS2 antibody, hcox-2 antibody, fj02a10 antibody, ptgs2 antibody, unp1239 antibody, wu:fj02a10 antibody, zCOX-2 antibody, si:dkey-97o5.6 antibody, prostaglandin-endoperoxide synthase 2 antibody, prostaglandin G/H synthase 2 antibody, prostaglandin-endoperoxide synthase 2S homeolog antibody, prostaglandin-endoperoxide synthase 2a antibody, prostaglandin-endoperoxide synthase 2b antibody, PTGS2 antibody, Ptgs2 antibody, LOC100136456 antibody, ptgs2.S antibody, ptgs2 antibody, ptgs2a antibody, ptgs2b antibody
    Background
    Glucocorticoid-regulated inflammatory Prostaglandin G/H synthase, GRIPGHS, Macrophage activation-associated marker protein P71/73, PES-2, PGG/HS, PGHS-2, Prostaglandin endoperoxide synthase 2, Prostaglandin endoperoxide synthase 2 (PTGS2), TIS10,Cycloxygenase-2 (COX-2)
    Cellular localisation: Cytoplasmic
    Molecular Weight
    70-72kDa
    Gene ID
    5743, 196384
    UniProt
    P35354
    Pathways
    Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation
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