Spastin antibody
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- Target See all Spastin (SPAST) Antibodies
- Spastin (SPAST)
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This Spastin antibody is un-conjugated
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Application
- Western Blotting (WB), Immunofluorescence (IF)
- Specificity
- The AAA protein family members share an ATPase domain and have roles in various cellular processes including intracellular motility, membrane trafficking, proteolysis, protein folding and organelle biogenesis. Spastin, a member of the AAA protein family, is a 616 amino acid protein and is involved in the function or assembly of nuclear protein complexes. The Spastin protein is expressed ubiquitously and localizes to the nucleus and the cytoplasm, where it may also be involved in microtubule dynamics. Mutations in the Spastin gene (SPAST, SPG4) cause the most common form of spastic paraplegia 4, an autosomal dominant form of hereditary spastic paraplegia (HSP). HSPs comprise a group of inherited neurological disorders characterized by spastic lower extremity weakness due to a length-dependent, retrograde axonopathy of corticospinal motor neurons. SPAST-specific mutations account for approximately 40 % of all autosomal dominant HSPs.
- Cross-Reactivity (Details)
- Human. Mouse. Rat.
- Purification
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogen
- Recombinant full-length human Spastin protein.
- Clone
- Sp 6C6
- Isotype
- IgG2a kappa
- Top Product
- Discover our top product SPAST Primary Antibody
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- Application Notes
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Known_Application: Immunofluorescence (1-2 μg/mL), ,Western Blot (1-2 μg/mL),Optimal dilution for a specific application should be determined.
Positive_Control: HeLa cells. K-562 or Raji cell lysates.
- Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Preservative
- Azide free
- Storage
- -20 °C,-80 °C
- Storage Comment
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Expiry Date
- 24 months
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- Target
- Spastin (SPAST)
- Alternative Name
- SPAST (SPAST Products)
- Synonyms
- CG5977 antibody, D-spastin antibody, Dmel\\CG5977 antibody, Dspastin antibody, Spas antibody, zgc:85952 antibody, SPAST antibody, spg4 antibody, LOC100224472 antibody, ADPSP antibody, FSP2 antibody, SPG4 antibody, Spg4 antibody, mKIAA1083 antibody, spastin antibody, spastin S homeolog antibody, spas antibody, spast antibody, SPAST antibody, Spast antibody, spast.S antibody
- Background
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ADPSP, FSP2, Spast, Spatin, SPG4,Spastin
Cellular localisation: Cell Membrane and Secreted. - Molecular Weight
- 52kDa
- Gene ID
- 6683, 468091
- Pathways
- Microtubule Dynamics, M Phase, Regulation of Cell Size
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