Recombinant TNFSF15 antibody
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- Target See all TNFSF15 Antibodies
- TNFSF15 (Tumor Necrosis Factor (Ligand) Superfamily, Member 15 (TNFSF15))
- Antibody Type
- Recombinant Antibody
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Monoclonal
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Conjugate
- This TNFSF15 antibody is un-conjugated
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Application
- Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- Specificity
- VEGI is an anti-angiogenic cytokine that belongs to tumor necrosis factor superfamily, member 15 (TNFSF15). This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Reduced expression of VEGI has been reported as a marker of poor prognosis in breast cancer.
- Cross-Reactivity (Details)
- Human.
- Purification
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogen
- Recombinant full-length human VEGI protein
- Clone
- VEGI-2052R
- Isotype
- IgG
- Top Product
- Discover our top product TNFSF15 Primary Antibody
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- Application Notes
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Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.
Positive_Control: Endothelial cells. Colon, intestine, placenta, lung, liver, kidney, pancreas, spleen or prostate.
- Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Preservative
- Azide free
- Storage
- -20 °C,-80 °C
- Storage Comment
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Expiry Date
- 24 months
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- Target
- TNFSF15 (Tumor Necrosis Factor (Ligand) Superfamily, Member 15 (TNFSF15))
- Alternative Name
- TNFSF15 (TNFSF15 Products)
- Synonyms
- TTPAL antibody, TL1 antibody, TL1A antibody, VEGI antibody, VEGI192A antibody, Tl1 antibody, Tl1a antibody, Vegi antibody, tumor necrosis factor superfamily member 15 antibody, TNF superfamily member 15 antibody, tumor necrosis factor (ligand) superfamily, member 15 antibody, TNFSF15 antibody, Tnfsf15 antibody
- Background
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TNF ligand-related molecule 1 (TL1A), Tumor necrosis factor (ligand) superfamily member 15 (TNFSF15), Vascular endothelial growth inhibitor 192a, Vascular endothelial growth inhibitor (VEGI), VEGI192A,TNFS15 / VEGI (Vascular Endothelial Growth Inhibitor)
Cellular localisation: Secreted and Cell Surface - Molecular Weight
- 22kDa
- Gene ID
- 9966, 241382
- UniProt
- O95150
- Pathways
- Positive Regulation of Endopeptidase Activity, Autophagy
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