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N-Cadherin antibody (Cytoplasmic Domain)

CDH2 Reactivity: Human WB, IF, FACS Host: Mouse Monoclonal 13A9 unconjugated
Catalog No. ABIN6934766
  • Target See all N-Cadherin (CDH2) Antibodies
    N-Cadherin (CDH2) (Cadherin 2 (CDH2))
    Binding Specificity
    • 22
    • 15
    • 14
    • 8
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cytoplasmic Domain
    Reactivity
    • 142
    • 96
    • 68
    • 21
    • 16
    • 14
    • 8
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Host
    • 92
    • 57
    • 4
    • 4
    • 2
    Mouse
    Clonality
    • 85
    • 74
    Monoclonal
    Conjugate
    • 82
    • 15
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This N-Cadherin antibody is un-conjugated
    Application
    • 112
    • 54
    • 42
    • 39
    • 25
    • 23
    • 17
    • 14
    • 14
    • 13
    • 12
    • 8
    • 4
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)
    Specificity
    Recognizes a protein of ~140 kDa, identified as N-Cadherin (NCAD), also known as CD325. NCAD is a member of the Cadherin superfamily, and consists of five extracellular repeats, a transmembrane domain and a cytoplasmic domain. CD325 deficient mice die at day 10 of gestation and embryos display major heart defects and malformed neural tubes and somites. Consistent with this, CD325 has been implicated in several aspects of cardiac development including the precardiac mesoderm, establishment of left-right symmetry and cardiac looping morphogenesis. Furthermore, CD325 is normally involved in inducing cell cycle arrest and its expression is frequently deregulated in cancer cells.Studies have linked N-cadherin to cancer metastasis by showing the aggressive tumor cells had preferentially turned on N-cadherin as opposed to E- or P-cadherin.
    Cross-Reactivity (Details)
    Human and Mouse. Others not known.
    Purification
    200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.
    Immunogen
    Recombinant human N-cadherin cytoplasmic domain
    Clone
    13A9
    Isotype
    IgG1
    Top Product
    Discover our top product CDH2 Primary Antibody
  • Application Notes

    Positive Control: HeLa or HUVEC cells. Heart, Pancreas or Cerebral Cortex

    Known Application: Flow Cytometry (1-2 μg/million cells), ,Immunofluorescence (1-2 μg/mL), ,Western Blotting (1-2 μg/mL), ,Optimal dilution for a specific application should be determined.

    Restrictions
    For Research Use only
  • Concentration
    200 μg/mL
    Buffer
    Prepared in 10 mM PBS with 0.05 % BSA and 0.05 % azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-80 °C
    Storage Comment
    Antibody with azide - store at 2 to 8 °C. Antibody is stable for 24 months. Non-hazardous. Also available WITHOUT BSA & azide at 1.0mg/ml.
    Expiry Date
    24 months
  • Target
    N-Cadherin (CDH2) (Cadherin 2 (CDH2))
    Alternative Name
    CDH2 (CDH2 Products)
    Synonyms
    CD325 antibody, CDHN antibody, CDw325 antibody, NCAD antibody, N-cadherin antibody, cadherin-2 antibody, cdhn antibody, ncad antibody, cdw325 antibody, CDH2 antibody, Cadherin-2 antibody, Ncad antibody, glo antibody, lyr antibody, pac antibody, wu:fb47h04 antibody, cadherin 2 antibody, cadherin 2 S homeolog antibody, cadherin 2, type 1, N-cadherin (neuronal) antibody, CDH2 antibody, cdh2.S antibody, cdh2 antibody, Cdh2 antibody
    Background
    Cadherin-2 N cadherin neuronal, Cadherin-2 type 1, Cadherin-2, Calcium dependent adhesion protein neuronal, CD325, CDH2, CDHN, CDw325, N-Cadherin, NCAD,N-Cadherin / Cadherin-2 / CD325 (NCAD)
    Cellular localisation: Cell surface
    Molecular Weight
    130-140kDa
    Gene ID
    1000, 464829
    UniProt
    P19022
    Pathways
    Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Synaptic Membrane
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