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DMC1 antibody

DMC1 Reactivity: Human, Mouse, Rat, Cow WB, IHC, IF, StM Host: Mouse Monoclonal 2H12-4 unconjugated
Catalog No. ABIN6939141
  • Target See all DMC1 Antibodies
    DMC1 (DNA Meiotic Recombinase 1 (DMC1))
    Reactivity
    • 56
    • 7
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Cow
    Host
    • 49
    • 7
    Mouse
    Clonality
    • 50
    • 6
    Monoclonal
    Conjugate
    • 28
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This DMC1 antibody is un-conjugated
    Application
    • 49
    • 29
    • 20
    • 14
    • 13
    • 13
    • 9
    • 6
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Staining Methods (StM)
    Purification
    Purified by Protein A/G
    Immunogen
    Recombinant full-length human DMC1 protein.
    Clone
    2H12-4
    Isotype
    IgG2a kappa
    Top Product
    Discover our top product DMC1 Primary Antibody
  • Application Notes

    Positive Control: HeLa cells. Cervix or prostate.

    Known Application: Immunofluorescence (0.5-1 μg/mL), Western Blot (0.5-1.0 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    Restrictions
    For Research Use only
  • Concentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-80 °C
    Storage Comment
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Expiry Date
    24 months
  • Target
    DMC1 (DNA Meiotic Recombinase 1 (DMC1))
    Alternative Name
    DMC1 (DMC1 Products)
    Synonyms
    DMC1 antibody, zgc:136628 antibody, Dmc1h antibody, Lim15 antibody, Mei11 antibody, sgdp antibody, DCM1 antibody, DMC1H antibody, LIM15 antibody, dJ199H16.1 antibody, DNA meiotic recombinase 1 antibody, DMC1 antibody, dmc1 antibody, Dmc1 antibody
    Background
    DNA repair proteins are necessary for the maintenance of chromosome integrity and are involved in the elimination of premutagenic lesions from DNA. The DNA repair proteins Rad51 and Rad52 are key components of the doublestrand-break repair (DSBR) pathway. Rad51 is essential for mitotic and meiotic recombination, and its mutation in yeast and mammalian cells results in chromosome loss. Overexpression of Rad52 confers resistance to ionizing radiation and induces homologous intrachromosomal recombination. Rad52 is thought to be involved in an early stage of Rad51-mediated recombination. Additional proteins involved in the pathway include Nibrin and Dmc1. Nibrin, which complexes with Mre11 and Rad50, is absent in Nijemegen breakage syndrome (NBS) patients. Dmc1 is specifically involved in meiotic recombination. An alternative spliced form of Dmc1, designated Dmc1-D, is deleted for a region between the two motifs involved in nucleotide binding. The alternatively spliced Dmc1-D transcript is detected in both male and female germ cells, indicating that the encoded protein may have a role in mammalian genetic recombination in meiosis.
    Molecular Weight
    37kDa
    Gene ID
    11144
    UniProt
    Q14565
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