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Recombinant MTAP antibody (AA 97-196)

MTAP Reactivity: Human IHC, StM, ISt Host: Mouse Monoclonal rMTAP-1813 unconjugated Recombinant Antibody
Catalog No. ABIN6940088
  • Target See all MTAP Antibodies
    MTAP (Methylthioadenosine phosphorylase (MTAP))
    Antibody Type
    Recombinant Antibody
    Binding Specificity
    • 14
    • 9
    • 8
    • 7
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 97-196
    Reactivity
    • 54
    • 13
    • 7
    • 6
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 49
    • 7
    Mouse
    Clonality
    • 45
    • 11
    Monoclonal
    Conjugate
    • 33
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MTAP antibody is un-conjugated
    Application
    • 43
    • 32
    • 12
    • 7
    • 7
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), Staining Methods (StM), Immunostaining (ISt)
    Specificity
    Recognizes a protein of 31 kDa, which is identified as MTAP (5'-deoxy-5'-methylthioadenosine phosphorylase). It catalyzes the reversible phosphorolysis of methylthioadenosine, which is important in polyamine metabolism and for the salvage of adenine and methionine. The gene encoding MTAP is linked to the tumor suppressor gene, p16INK4A. Deficient levels of MTAP can occur in cancers primarily through co-deletion of the MTAP gene and the p16INK4A gene. Cells expressing MTAP and possessing adenine salvage pathway activity may be less susceptible to malignancy due to growth-inhibitory actions of agents (e.g. antifolates), whose mechanism of action, in part, involves this de novo purine pathway.
    Purification
    Purified by Protein A/G
    Immunogen
    Recombinant human MTAP protein fragment (aa97-196) (exact sequence is proprietary)
    Clone
    RMTAP-1813
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product MTAP Primary Antibody
  • Application Notes

    Positive Control: HepG2, A431, HeLa or MCF-7 cells. Human kidney tissues (IHC).

    Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0 for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

    Restrictions
    For Research Use only
  • Concentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-80 °C
    Storage Comment
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Expiry Date
    24 months
  • Target
    MTAP (Methylthioadenosine phosphorylase (MTAP))
    Alternative Name
    MTAP (MTAP Products)
    Synonyms
    BDMF antibody, DMSFH antibody, DMSMFH antibody, LGMBF antibody, MSAP antibody, c86fus antibody, Cc1-6 antibody, 1300019I21Rik antibody, MTAPase antibody, zgc:66012 antibody, mtap antibody, methylthioadenosine phosphorylase antibody, 5'-methylthioadenosine phosphorylase antibody, 6-oxopurine nucleoside phosphorylase antibody, methylthioadenosine phosphorylase L homeolog antibody, MTAP antibody, Mtap antibody, mtaP antibody, MMAH_RS04260 antibody, TAGG_RS05050 antibody, Toce_0364 antibody, VDIS_RS03165 antibody, MFER_RS02485 antibody, Intca_0886 antibody, DESMU_RS05370 antibody, Dester_1490 antibody, ARCVE_RS05445 antibody, Mahau_1873 antibody, MZHIL_RS01440 antibody, mtap antibody, mtap.L antibody
    Molecular Weight
    31kDa
    Gene ID
    4507
    UniProt
    Q13126
    Pathways
    Ribonucleoside Biosynthetic Process, Methionine Biosynthetic Process
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