ARPC5 antibody
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- Target See all ARPC5 Antibodies
- ARPC5 (Actin Related Protein 2/3 Complex, Subunit 5, 16kDa (ARPC5))
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Reactivity
- Human, Rat, Mouse
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Host
- Rabbit
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Clonality
- Monoclonal
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Conjugate
- This ARPC5 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)
- Cross-Reactivity
- Human, Mouse, Rat
- Purification
- Purified by Protein A.
- Immunogen
- Recombinant human p16 ARC around N-terminus
- Clone
- 8D8
- Isotype
- IgG
- Top Product
- Discover our top product ARPC5 Primary Antibody
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- Application Notes
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WB 1:300-5000
FCM 1:20-100
IHC-P 1:200-400
IF(ICC) 1:50-200
IHC() - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C for 12 months.
- Expiry Date
- 12 months
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- Target
- ARPC5 (Actin Related Protein 2/3 Complex, Subunit 5, 16kDa (ARPC5))
- Alternative Name
- p16 ARC (ARPC5 Products)
- Synonyms
- arc16 antibody, p16-arc antibody, ARPC5 antibody, APOBEC4 antibody, ARC16 antibody, dJ127C7.3 antibody, p16-Arc antibody, MGC86407 antibody, 5830443F10Rik antibody, arpc5 antibody, fb09c07 antibody, fb12b05 antibody, fc56c07 antibody, wu:fb09c07 antibody, wu:fb12b05 antibody, wu:fc56c07 antibody, actin related protein 2/3 complex subunit 5 antibody, actin related protein 2/3 complex subunit 5 L homeolog antibody, actin related protein 2/3 complex, subunit 5 antibody, actin related protein 2/3 complex, subunit 5B antibody, actin related protein 2/3 complex, subunit 5A antibody, ARPC5 antibody, arpc5 antibody, arpc5.L antibody, Arpc5 antibody, arpc5b antibody, arpc5a antibody
- Background
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Synonyms: Actin-related protein 2/3 complex subunit 5, Arp2/3 complex 16 kDa subunit, p16-ARC, ARPC5
Background: Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).
- Gene ID
- 10092
- UniProt
- O15511
- Pathways
- RTK Signaling, Regulation of Actin Filament Polymerization
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